RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation
文献类型：期刊论文
| 作者 | Ruan, Yuanyuan1; Guo, Liang1; Qiao, Ying2; Hong, Yi1; Zhou, Lei1; Sun, Linlin1; Wang, Lijing1; Zhu, Haiyan1; Wang, Lan1; Yun, Xiaojing1 |
| 刊名 | biochemical and biophysical research communications
 |
| 出版日期 | 2009-12-11 |
| 卷号 | 390期号:2页码:217-222 |
| 关键词 | CLEC-2 RACK1 Ubiquitination Degradation |
| 英文摘要 | clec-2 is a c-type lectin-like receptor and plays an important role in platelet activation. snake venom toxin rhodocytin and the endogenous sialoglycoprotein podoplanin are identified as ligands for clec-2 and function as stimulators in platelet activation. we also previously indentified two splice variants of murine clec-2 as well as a soluble fragment cleaved from the full-length form. however, little is known about the interacting partners with the cytoplasmic region of clec-2. in this study, we reported that rack1, the receptor for activated c-kinase 1, associated with the cytoplasmic tail of clec-2. moreover, overexpression of rack 1 decreased the stability of clec-2 through promoting its ubiquitin-proteasome degradation, without impairing surface expression and downstream signaling of clec-2. taken together, these results suggest rack1 as a novel modulator of clec-2 expression. (c) 2009 elsevier inc. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology ; biophysics |
| 研究领域[WOS] | biochemistry & molecular biology ; biophysics |
| 关键词[WOS] | molecular characterization ; platelet activation ; receptor clec-2 ; cancer-cells ; dc-sign ; protein ; mediate |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271552400009 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141483]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Fudan Univ, Shanghai Med Coll, Ctr Gene Res, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ruan, Yuanyuan,Guo, Liang,Qiao, Ying,et al. RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation[J]. biochemical and biophysical research communications,2009,390(2):217-222. |
| APA | Ruan, Yuanyuan.,Guo, Liang.,Qiao, Ying.,Hong, Yi.,Zhou, Lei.,...&Gu, Jianxin.(2009).RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation.biochemical and biophysical research communications,390(2),217-222. |
| MLA | Ruan, Yuanyuan,et al."RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation".biochemical and biophysical research communications 390.2(2009):217-222. |
入库方式： OAI收割
来源：大连化学物理研究所
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