Investigation of Propofol Concentrations in Human Breath by Solid-phase Microextraction Gas Chromatography-Mass Spectrometry
文献类型：期刊论文
| 作者 | Gong, Y.1; Li, E.1; Xu, G.2; Wang, H.1; Wang, C.1; Li, P.1; He, Y.1 |
| 刊名 | journal of international medical research
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 37期号:5页码:1465-1471 |
| 关键词 | ANAESTHESIA PROPOFOL EXHALED GAS PLASMA SOLID-PHASE MICROEXTRACTION GAS CHROMATOGRAPHY-MASS SPECTROMETRY |
| 英文摘要 | propofol has been detected in human breath after being used as an intravenous anaesthetic, and this could provide a noninvasive method for monitoring propofol anaesthesia. the physicochemical properties of propofol allow it to diffuse across the alveolocapillary membrane and to be prepared as a calibration gas. in this study, headspace solid-phase microextraction gas chromatography-mass spectrometry (hs-spme-gc-ms), coupled with an external standard, was applied to assess propofol levels in the breath and plasma from three subjects under intravenous anaesthesia. lower quantitation limits were 3.6 ng/l and 0.2 mg/l for propofol analysis in breath and arterial plasma, respectively. intraday precision and recovery percentages for propofol detection in breath were 4.3 - 6.7% and 98 - 108%, respectively, and in plasma they were 3.8 - 6.1% and 90.1 - 125.1%, respectively. propofol concentrations were 4.3 - 33.5 ng/l in breath and 3.2 - 6.8 mg/l in arterial plasma. a correlation was shown between propofol concentration in breath and plasma. thus, hs-spme-gc-ms, coupled with an external standard, could be a reliable and sensitive analytical technique for detecting propofol in breath during anaesthesia. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | medicine, research & experimental ; pharmacology & pharmacy |
| 研究领域[WOS] | research & experimental medicine ; pharmacology & pharmacy |
| 关键词[WOS] | anesthesia ; plasma |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000273133200022 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141579]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Harbin Med Coll, Dept Anaesthesiol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, Y.,Li, E.,Xu, G.,et al. Investigation of Propofol Concentrations in Human Breath by Solid-phase Microextraction Gas Chromatography-Mass Spectrometry[J]. journal of international medical research,2009,37(5):1465-1471. |
| APA | Gong, Y..,Li, E..,Xu, G..,Wang, H..,Wang, C..,...&He, Y..(2009).Investigation of Propofol Concentrations in Human Breath by Solid-phase Microextraction Gas Chromatography-Mass Spectrometry.journal of international medical research,37(5),1465-1471. |
| MLA | Gong, Y.,et al."Investigation of Propofol Concentrations in Human Breath by Solid-phase Microextraction Gas Chromatography-Mass Spectrometry".journal of international medical research 37.5(2009):1465-1471. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。