Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450
文献类型：期刊论文
| 作者 | Chen, Jianjun1; Zhang, Jiang-Wei2; Yang, Ling2; Li, Wei1 |
| 刊名 | chemical & pharmaceutical bulletin
 |
| 出版日期 | 2009-08-01 |
| 卷号 | 57期号:8页码:835-839 |
| 关键词 | Medroxyprogesterone acetate metabolite P450 enzyme NMR structure elucidation |
| 英文摘要 | we previously reported the separation and identification for the major metabolites from incubating medroxyprogesterone acetate (mpa) with p450. the structure assignments for these metabolites were tentatively assigned based on one-dimensional (1d) proton nmr. unambiguous structure identification of these metabolites is critical to study biological pathways of p450. here we report the complete structure elucidation by extensive two-dimensional (2d) nmr for the three major metabolites isolated in our earlier studies. the three major metabolites (namely m-2, m-3, m-4) were unambiguously identified to be 6 beta-, 1 beta-, and 2 beta-hydroxy mpa. the current work confirmed the speculated structures for these metabolites in our previous studies. more importantly, the unambiguous structural information and the establishment for their nmr chemical shifts of these metabolites can serve as reference standards for future studies. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | chemistry, medicinal ; chemistry, multidisciplinary ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy ; chemistry |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000268547300009 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141585]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Univ Tennessee, Ctr Hlth Sci, Coll Pharm, Dept Pharmaceut Sci, Memphis, TN 38163 USA 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jianjun,Zhang, Jiang-Wei,Yang, Ling,et al. Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450[J]. chemical & pharmaceutical bulletin,2009,57(8):835-839. |
| APA | Chen, Jianjun,Zhang, Jiang-Wei,Yang, Ling,&Li, Wei.(2009).Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450.chemical & pharmaceutical bulletin,57(8),835-839. |
| MLA | Chen, Jianjun,et al."Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450".chemical & pharmaceutical bulletin 57.8(2009):835-839. |
入库方式： OAI收割
来源：大连化学物理研究所
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