Multiple reactivities of dithranol towards 1-alkynyl Fischer carbene complexes (CO)(5)M=C(OEt)C CPh (M = Cr, W) - Efficient chemical synthesis of aromatic polyketides
文献类型：期刊论文
| 作者 | Luo, Ning1; Yu, Zhengkun1,2 |
| 刊名 | journal of organometallic chemistry
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 694期号:19页码:3058-3067 |
| 关键词 | Fischer carbene Dithranol Multiple reactivity Polyketides Polycarbene |
| 英文摘要 | reactions of anti-psoriasis drug dithranol with 1-alkynyl fischer carbene complexes (co)(5)m =c(oet)c cph (m = cr, w) were investigated under controlled conditions in which triethylamine-promoted c-addition, o-addition, electrophilic aromatic substitution, and cyclization consecutively occurred at up to five positions of dithranol. a remarkable solvent effect led to selective formation of polyphenolic organic and organometallic mono- and triscarbene complexes which were efficiently demetalated to the potentially bioactive aromatic polyketides with pyridine-n-oxide. all the organic and organometallic products were characterized by methods including x-ray single crystal structural determinations. these results have revealed the novel multiple reactivities of dithranol which might be associated to its clinical side effect, providing a new synthetic methodology to functionalize dithranol for medical purposes, and chemically synthesize aromatic polyketides. (c) 2009 elsevier b. v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, inorganic & nuclear ; chemistry, organic |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | h insertion ; pathway ; chromium ; demetalation ; anthracene |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000268799500003 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141623]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Ning,Yu, Zhengkun. Multiple reactivities of dithranol towards 1-alkynyl Fischer carbene complexes (CO)(5)M=C(OEt)C CPh (M = Cr, W) - Efficient chemical synthesis of aromatic polyketides[J]. journal of organometallic chemistry,2009,694(19):3058-3067. |
| APA | Luo, Ning,&Yu, Zhengkun.(2009).Multiple reactivities of dithranol towards 1-alkynyl Fischer carbene complexes (CO)(5)M=C(OEt)C CPh (M = Cr, W) - Efficient chemical synthesis of aromatic polyketides.journal of organometallic chemistry,694(19),3058-3067. |
| MLA | Luo, Ning,et al."Multiple reactivities of dithranol towards 1-alkynyl Fischer carbene complexes (CO)(5)M=C(OEt)C CPh (M = Cr, W) - Efficient chemical synthesis of aromatic polyketides".journal of organometallic chemistry 694.19(2009):3058-3067. |
入库方式： OAI收割
来源：大连化学物理研究所
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