Rh-Catalyzed Oxidative Coupling between Primary and Secondary Benzamides and Alkynes: Synthesis of Polycyclic Amides
文献类型：期刊论文
| 作者 | Song, Guoyong1; Chen, Dan1; Pan, Cheng-Ling1; Crabtree, Robert H.3; Li, Xingwei1,2 |
| 刊名 | journal of organic chemistry
 |
| 出版日期 | 2010-11-05 |
| 卷号 | 75期号:21页码:7487-7490 |
| 英文摘要 | a methodology for the high yield and facile synthesis of isoquinolones from benzamides and alkynes via the oxidative ortho c-h activation of benzamides has been developed. ag(2)co(3) proved to be an optimal oxidant when mecn was used as a solvent, and [rhcp*cl(2)](2), was utilized as an efficient catalyst. both n-alkyl and n-aryl secondary benzamides can be applied as effective substrates. furthermore, primary benzamides react with two alkyne units, leading to tricyclic products via double c-h activation and oxidative coupling. the reactivity of the structurally related 1-hydroxyisoquinoline was also demonstrated, where both n- and o-containing rhodacyclic intermediates can be generated, leading to the construction of different o- or n-containing heterocycles. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, organic |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | h bond-cleavage ; c-h ; internal alkynes ; benzoic-acids ; activation ; coupling/cyclization ; arylation ; cycloaddition ; temperature ; derivatives |
| 收录类别 | SCI ; IC ; CCR |
| 语种 | 英语 |
| WOS记录号 | WOS:000283531100064 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141727]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Scripps Res Inst, Jupiter, FL 33458 USA 3.Yale Univ, Dept Chem, New Haven, CT 06520 USA |
| 推荐引用方式 GB/T 7714 | Song, Guoyong,Chen, Dan,Pan, Cheng-Ling,et al. Rh-Catalyzed Oxidative Coupling between Primary and Secondary Benzamides and Alkynes: Synthesis of Polycyclic Amides[J]. journal of organic chemistry,2010,75(21):7487-7490. |
| APA | Song, Guoyong,Chen, Dan,Pan, Cheng-Ling,Crabtree, Robert H.,&Li, Xingwei.(2010).Rh-Catalyzed Oxidative Coupling between Primary and Secondary Benzamides and Alkynes: Synthesis of Polycyclic Amides.journal of organic chemistry,75(21),7487-7490. |
| MLA | Song, Guoyong,et al."Rh-Catalyzed Oxidative Coupling between Primary and Secondary Benzamides and Alkynes: Synthesis of Polycyclic Amides".journal of organic chemistry 75.21(2010):7487-7490. |
入库方式： OAI收割
来源：大连化学物理研究所
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