Palladium-Catalyzed Coupling Reaction of alpha-Diazocarbonyl Compounds with Aromatic Boronic Acids or Halides
文献类型：期刊论文
| 作者 | Peng, Cheng; Yan, Guobin; Wang, Yan; Jiang, Yubo; Zhang, Yan; Wang, Jianbo |
| 刊名 | synthesis-stuttgart
 |
| 出版日期 | 2010-12-01 |
| 期号 | 24页码:4154-4168 |
| 关键词 | palladium catalysis cross-coupling diazo compounds aryl halides arylboronic acids |
| 英文摘要 | efficient palladium-catalyzed cross-coupling reactions of alpha-diazocarbonyl compounds and arylboronic acids or aryl halides have been developed. the reaction proceeds smoothly for a range of diazo compounds, boronic acids, and halides. the coupling reaction conditions tolerate various substituents on the aromatic rings of the substrates, such as chloro, fluoro, acyl, oxo, ester, and nitro groups. this coupling reaction constitutes a novel access to alpha-aryl-substituted alpha,beta-unsaturated carbonyl compounds. mechanistically, palladium-carbene is supposed to be the key intermediate; its formation is followed by migratory insertion of an aryl group to the carbenic carbon of the palladium-carbene complex and subsequent beta-hydride elimination. kinetic isotope effect (kie) data measured for intra- and intermolecular competition experiments suggest that beta-hydride elimination is not involved in the rate-determining step. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, organic |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | n-heterocyclic carbenes ; beta-hydride elimination ; organic-synthesis ; asymmetric cyclopropanation ; stereoselective-synthesis ; migratory insertion ; aryl halides ; mediated copolymerization ; carbonylation reactions ; stabilized carbene |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000286479200002 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141875]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Cheng,Yan, Guobin,Wang, Yan,et al. Palladium-Catalyzed Coupling Reaction of alpha-Diazocarbonyl Compounds with Aromatic Boronic Acids or Halides[J]. synthesis-stuttgart,2010(24):4154-4168. |
| APA | Peng, Cheng,Yan, Guobin,Wang, Yan,Jiang, Yubo,Zhang, Yan,&Wang, Jianbo.(2010).Palladium-Catalyzed Coupling Reaction of alpha-Diazocarbonyl Compounds with Aromatic Boronic Acids or Halides.synthesis-stuttgart(24),4154-4168. |
| MLA | Peng, Cheng,et al."Palladium-Catalyzed Coupling Reaction of alpha-Diazocarbonyl Compounds with Aromatic Boronic Acids or Halides".synthesis-stuttgart .24(2010):4154-4168. |
入库方式： OAI收割
来源：大连化学物理研究所
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