Genome-wide analysis of recombination machinery for spliceosomal introns gain
文献类型：期刊论文
| 作者 | Tan, Haidong |
| 刊名 | molecular biology reports
 |
| 出版日期 | 2010-03-01 |
| 卷号 | 37期号:3页码:1551-1557 |
| 关键词 | Sex chromosomes Autosomes Recombination Spliceosomal introns |
| 英文摘要 | what caused spliceosomal introns gain remains an unsolved problem. to this, defining what spliceosomal introns arise from is critical. here, the introns density of the genomes is calculated for four species, indicating:(1) sex chromosomes in mammals have lower intron densities, (2) despite that, the proportion of utrs (untranslated regions) with introns in sex chromosomes is higher than other ones, and (3) at content of introns is more similar to that of intergenic regions when these regions comprise the majority of a chromosome, and more similar to that of exons, when exons are the majority of the chromosome. on the other hand, introns have been clearly demonstrated to invade genetic sequences in recent times while sex chromosomes evolved from a pair of autosomes within the last 300 millions years. one main difference between sex chromosomes and autosomes in mammalian is that sex chromosomes recombination stopped. thus, recombination might be the main determinant for eukaryotes gaining spliceosomal introns. to further prove that and avoid giving weak signal, the whole genomes from eight eukaryotic species are analyzed and present strong signal for above the trend (3) in three species (t-test, p = 0.55 for c. elegans, p = 0.72 for d. melanogaster and p = 0.83 for a. thaliana). these results suggest that the genome-wide coincidence as above (3) can only be caused by the large-scale random unequal crossover in eukaryote meiosis, which might have fueled spliceosomal introns but hardly occurred in prokaryotes. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | double-strand breaks ; quantitative genetic-variation ; mitochondrial-dna ; x-chromosome ; evolution ; database ; meiosis ; model ; drosophila ; sequence |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000274212500050 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141876]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Haidong. Genome-wide analysis of recombination machinery for spliceosomal introns gain[J]. molecular biology reports,2010,37(3):1551-1557. |
| APA | Tan, Haidong.(2010).Genome-wide analysis of recombination machinery for spliceosomal introns gain.molecular biology reports,37(3),1551-1557. |
| MLA | Tan, Haidong."Genome-wide analysis of recombination machinery for spliceosomal introns gain".molecular biology reports 37.3(2010):1551-1557. |
入库方式： OAI收割
来源：大连化学物理研究所
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