Synthesis and Characterization of Amphiphilic Glycidol-Chitosan-Deoxycholic Acid Nanoparticles as a Drug Carrier for Doxorubicin
文献类型：期刊论文
| 作者 | Zhou, Huofei2,3; Yu, Weiting2; Guo, Xin2; Liu, Xiudong1; Li, Nan2; Zhang, Ying2; Ma, Xiaojun2 |
| 刊名 | biomacromolecules
 |
| 出版日期 | 2010-12-01 |
| 卷号 | 11期号:12页码:3480-3486 |
| 英文摘要 | novel amphiphilic chitosan derivatives (glycidol chitosan deoxycholic acid, g-cs-dca) were synthesized by grafting hydrophobic moieties, deoxycholic acid (dca), and hydrophilic moieties, glycidol, with the purpose of preparing carriers for poorly soluble drugs. based on self-assembly. g-cs-dca can form nanoparticles with size ranging from 160 to 210 nm, and g-cs-dca nanoparticles maintained stable structure for about 3 months when stored in pbs (ph 7.4) at room temperature. the critical aggregation concentration decreased from 0.043 mg/ml to 0.013 mg/ml with the increase of degree of substitution (ds) of dca. doxorubicin (dox) could be easily encapsulated into g-cs-dca nanoparticles and keep a sustained release manner without burst release when exposed to pbs (ph 7.4) at 37 degrees c. antitumor efficacy results showed that dox-g-cs-dca have significant antitumor activity when mcf-7 cells were incubated with different concentration of dox-g-cs-dca nanoparticles. the fluorescence imaging results indicated dox-g-cs-dca nanoparticles could easily be uptaken by mcf-7 cells. these results suggested that g-cs-dca nanoparticles may be a promising carrier for dox delivery in cancer therapy. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemistry & molecular biology ; chemistry, organic ; polymer science |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry ; polymer science |
| 关键词[WOS] | polymeric micelles ; insulin delivery ; plasmid dna ; derivatives ; paclitaxel ; complexes ; systems ; gene |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285267500031 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141877]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Univ Technol, Coll Environm & Chem Engn, Dalian 116622, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Huofei,Yu, Weiting,Guo, Xin,et al. Synthesis and Characterization of Amphiphilic Glycidol-Chitosan-Deoxycholic Acid Nanoparticles as a Drug Carrier for Doxorubicin[J]. biomacromolecules,2010,11(12):3480-3486. |
| APA | Zhou, Huofei.,Yu, Weiting.,Guo, Xin.,Liu, Xiudong.,Li, Nan.,...&Ma, Xiaojun.(2010).Synthesis and Characterization of Amphiphilic Glycidol-Chitosan-Deoxycholic Acid Nanoparticles as a Drug Carrier for Doxorubicin.biomacromolecules,11(12),3480-3486. |
| MLA | Zhou, Huofei,et al."Synthesis and Characterization of Amphiphilic Glycidol-Chitosan-Deoxycholic Acid Nanoparticles as a Drug Carrier for Doxorubicin".biomacromolecules 11.12(2010):3480-3486. |
入库方式： OAI收割
来源：大连化学物理研究所
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