Preparative separation of major xanthones from mangosteen pericarp using high-performance centrifugal partition chromatography
文献类型：期刊论文
| 作者 | Shan, Yichu1,2; Zhang, Wei2 |
| 刊名 | journal of separation science
 |
| 出版日期 | 2010-05-01 |
| 卷号 | 33期号:9页码:1274-1278 |
| 关键词 | High-performance centrifugal partition chromatography alpha-Mangostin gamma-Mangostin Mangosteen fruit pericarp Xanthones |
| 英文摘要 | mangosteen fruit pericarp (mfp) is a rich source of xanthones, which has shown remarkable pharmacological activities. to isolate xanthones, previous methods included labor intensive and time-consuming solid-phase extractions (sephadex lh20, silica gel) and sequential solvent extraction. in this study, major xanthones (alpha- and gamma-mangostins) in mfp were isolated at high purity in one step utilizing high-performance centrifugal partition chromatography with solvent system composed of petroleum ether, ethyl acetate, methanol and water (10:5:5:1). in one run, 200 mg crude extract of mfp was injected and 55.4 mg alpha-mangostin and 12.4 mg gamma-mangostin were obtained with the purity of 93.6 and 98.4%, respectively. the yields of them were 86.3 and 76.3%, respectively. as alpha- and gamma-mangostins are reported to show potent antioxidant, anti-inflammatory and anticancer activities, this method can be used for the large-scale production of them for future in vitro and in vivo biological studies. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | counter-current chromatography ; medicinal-plant extracts ; garcinia-mangostana ; alpha-mangostin ; cell-lines ; purification ; apoptosis ; induction ; fruit ; hplc |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277938200012 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141936]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China 2.Flinders Univ S Australia, Mol Bioproc & Bioprod Lab, Dept Med Biotechnol, Sch Med, Adelaide, SA 5001, Australia |
| 推荐引用方式 GB/T 7714 | Shan, Yichu,Zhang, Wei. Preparative separation of major xanthones from mangosteen pericarp using high-performance centrifugal partition chromatography[J]. journal of separation science,2010,33(9):1274-1278. |
| APA | Shan, Yichu,&Zhang, Wei.(2010).Preparative separation of major xanthones from mangosteen pericarp using high-performance centrifugal partition chromatography.journal of separation science,33(9),1274-1278. |
| MLA | Shan, Yichu,et al."Preparative separation of major xanthones from mangosteen pericarp using high-performance centrifugal partition chromatography".journal of separation science 33.9(2010):1274-1278. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。