Chitosan oligosaccharides suppressant LPS binding to TLR4/MD-2 receptor complex
文献类型：期刊论文
| 作者 | Qiao, Ying1,2; Ruan, Yuanyuan3; Xiong, Chuannan1; Xu, Qingsong1; Wei, Peng1; Ma, Pan1; Bai, Xuefang1; Du, Yuguang1 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2010-09-05 |
| 卷号 | 82期号:2页码:405-411 |
| 关键词 | LPS IL-1 beta Chitosan oligosaccharides MAPKs NF-kappa B Binding |
| 英文摘要 | lipopolysaccharide, a potent activator of the immune system, elicits the production of pro-inflammatory mediators in immunocytes. toll-like receptor 4 (tlr4) and myeloid differentiation factor (md) 2 receptor complex is required for recognition and signaling of lps. previous study suggested water soluble chitosan decreased secretion of pro-inflammatory cytokines tnf-alpha and il-6. however, no studies have provided direct target and molecular mechanism of anti-inflammatory effect of chitosan oligosaccharide on lps-stimulated cells. in this study, we found that chitosan oligosaccharides significantly inhibited binding of lps to tlr4/md-2 receptor complex, thus attenuated activation of mitogen-activated protein kinases (mapks) and decreased nuclear translocation of nuclear factor-kappa b (nf-kappa b). finally, chitosan oligosaccharides reduced the production of pro-inflammatory mediator, such as il-1 beta and nitric oxide (no) in lps-stimulated raw 264.7 cells. therefore, chitosan oligosaccharides are potential inhibitive effector of lps. (c) 2010 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | radical scavenging activity ; nf-kappa-b ; septic shock ; in-vitro ; lipopolysaccharide-binding ; tlr4-md-2 complex ; molecular-weight ; gene-expression ; chitooligosaccharides ; protein |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000280574600026 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141958]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dept Biotechnol, Dalian 116023, Liaoning, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Fudan Univ, Shanghai Med Coll, Ctr Gene Res, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiao, Ying,Ruan, Yuanyuan,Xiong, Chuannan,et al. Chitosan oligosaccharides suppressant LPS binding to TLR4/MD-2 receptor complex[J]. carbohydrate polymers,2010,82(2):405-411. |
| APA | Qiao, Ying.,Ruan, Yuanyuan.,Xiong, Chuannan.,Xu, Qingsong.,Wei, Peng.,...&Du, Yuguang.(2010).Chitosan oligosaccharides suppressant LPS binding to TLR4/MD-2 receptor complex.carbohydrate polymers,82(2),405-411. |
| MLA | Qiao, Ying,et al."Chitosan oligosaccharides suppressant LPS binding to TLR4/MD-2 receptor complex".carbohydrate polymers 82.2(2010):405-411. |
入库方式： OAI收割
来源：大连化学物理研究所
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