Chitooligosaccharides inhibit nitric oxide mediated migration of endothelial cells in vitro and tumor angiogenesis in vivo
文献类型：期刊论文
| 作者 | Wu, Haige1,2; Yao, Ziang2; Bai, Xuefang1; Du, Yuguang1; Ma, Xiaojun1 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2010-10-15 |
| 卷号 | 82期号:3页码:927-932 |
| 关键词 | Chitooligosaccharides Endothelial cell Migration Angiogenesis NO |
| 英文摘要 | chitooligosaccharides (cos), with a polymerization degree of 2-8, were prepared by the enzymic hydrolysis of chitosan. the anti-angiogenic activity of cos in subcutaneous xenografts in mice has been studied for the first time. as nitric oxide (no) plays a critical role in angiogenesis, we investigated the relationship between cos and the no-mediated migration of endothelial cells. the results demonstrated that cos could suppress tumor angiogenesis and exhibit antioxidant activity by increasing the sod activity in kunming mice that were implanted with human breast cancer cells, dose-dependently. cos was able to inhibit the migration of endothelial cells induced by no. in addition, cos altered the polymerization of actin and antagonized the formation of membrane extensions that were triggered by no in endothelial cells. together, these results indicated that cos had anti-angiogenic activity in vivo and in vitro, and the inhibitory activity of cos on endothelial cell migration may be due to interference with the no signal transduction pathway. (c) 2010 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | fibroblast-growth-factor ; chitosan ; synthase |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281524900058 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141970]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Dalian Univ Technol, Bioengn Coll, Dalian 116622, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Haige,Yao, Ziang,Bai, Xuefang,et al. Chitooligosaccharides inhibit nitric oxide mediated migration of endothelial cells in vitro and tumor angiogenesis in vivo[J]. carbohydrate polymers,2010,82(3):927-932. |
| APA | Wu, Haige,Yao, Ziang,Bai, Xuefang,Du, Yuguang,&Ma, Xiaojun.(2010).Chitooligosaccharides inhibit nitric oxide mediated migration of endothelial cells in vitro and tumor angiogenesis in vivo.carbohydrate polymers,82(3),927-932. |
| MLA | Wu, Haige,et al."Chitooligosaccharides inhibit nitric oxide mediated migration of endothelial cells in vitro and tumor angiogenesis in vivo".carbohydrate polymers 82.3(2010):927-932. |
入库方式： OAI收割
来源：大连化学物理研究所
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