Chitosan oligosaccharides inhibit TNF-alpha-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways
文献类型：期刊论文
| 作者 | Liu, Hong-Tao1,2,3; Li, Wen-Ming1; Huang, Pei1; Chen, Wen-Juan1; Liu, Qi-Shun2; Bai, Xue-Fang2; Yu, Chao1; Du, Yu-Guang2 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2010-05-23 |
| 卷号 | 81期号:1页码:49-56 |
| 关键词 | Chitosan oligosaccharides Vascular cell adhesion molecule-1 Intercellular adhesion molecule-1 Tumor necrosis factor-alpha Mitogen-activated protein kinases Human umbilical vein endothelial cells |
| 英文摘要 | this study aimed to investigate the inhibitive effects of chitosan oligosaccharides (cos) on tumor necrosis factor (tnf)-alpha-induced over-expression of vascular adhesion molecule-1 (vcam-1) and intercellular adhesion molecule-1 (icam-1) in human umbilical vein endothelial cells (huvecs). we found that cos effectively inhibited tnf-alpha-induced expression of vcam-1 and icam-1 at the level of transcription and translation. signal transduction studies suggested that cos blocked tnf-alpha-induced activation of nf-kappa b, degradation of i kappa b alpha, and phosphorylation of p38 mapk and erk1/2. a further investigation showed that the nf-kappa b activation can be partly suppressed by p38 mapk inhibitor (58203580) and erk1/2 inhibitor (pd98059), which also ameliorated the mrna expression of vcam-1 and icam-1 in tnf-alpha-induced huvecs. additionally, cos decreased u937 monocyte adhesion to huvecs induced by tnf-alpha. our findings suggest that cos inhibit vcam-1 and icam-1 production in activated huvecs at least partly through the blockade of p38 and erk1/2 signaling pathways. (c) 2010 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | nf-kappa-b ; intercellular-adhesion molecule-1 ; nitric-oxide production ; smooth-muscle-cells ; map kinase ; in-vitro ; chitooligosaccharides ; activation ; macrophages ; cos |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277953500008 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/141985]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Nat Prod & Glycoengn Res, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 110864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Hong-Tao,Li, Wen-Ming,Huang, Pei,et al. Chitosan oligosaccharides inhibit TNF-alpha-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways[J]. carbohydrate polymers,2010,81(1):49-56. |
| APA | Liu, Hong-Tao.,Li, Wen-Ming.,Huang, Pei.,Chen, Wen-Juan.,Liu, Qi-Shun.,...&Du, Yu-Guang.(2010).Chitosan oligosaccharides inhibit TNF-alpha-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways.carbohydrate polymers,81(1),49-56. |
| MLA | Liu, Hong-Tao,et al."Chitosan oligosaccharides inhibit TNF-alpha-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways".carbohydrate polymers 81.1(2010):49-56. |
入库方式： OAI收割
来源：大连化学物理研究所
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