Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles
文献类型：期刊论文
| 作者 | Yu, Zhi-Xiang; Wang, Yi; Wang, Yuanyuan |
| 刊名 | chemistry-an asian journal
 |
| 出版日期 | 2010 |
| 卷号 | 5期号:5页码:1072-1088 |
| 关键词 | cycloaddition eight-membered carbocycles total synthesis transition metals |
| 英文摘要 | eight-membered carbocycles are found in a wide variety of natural products that exhibit a broad range of biological and medicinal activities (cf. the most potent anticancer drug, taxol). however, the synthesis of eight-membered carbocycles is quite challenging as traditional approaches are met with entropic and enthalpic penalties in the ring-forming transition states. these negative effects can be totally or partially avoided with the implementation of transition-metal-catalyzed/mediated cycloadditions. in this focus review, examples of elegant and efficient metal-catalyzed and some metal-mediated cycloadditions (including ni- catalyzed [4+4] and rh-catalyzed [4+2+2] and [5+2+1] reactions) are presented to illustrate this. application of these cycloaddition reactions in total synthesis is also presented to show the significance of these reactions in addressing challenges in natural product synthesis. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | higher-order cycloaddition ; ring-closing metathesis ; rh(i)-catalyzed (5+2)+1 cycloaddition ; 4+2 cycloisomerization reactions ; bifunctional chain molecules ; beta-carbon elimination ; medium-sized rings ; homo diels-alder ; 6-pi+2-pi cycloaddition ; conjugated dienes |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277724800008 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142206]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Peking Univ, BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Zhi-Xiang,Wang, Yi,Wang, Yuanyuan. Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles[J]. chemistry-an asian journal,2010,5(5):1072-1088. |
| APA | Yu, Zhi-Xiang,Wang, Yi,&Wang, Yuanyuan.(2010).Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles.chemistry-an asian journal,5(5),1072-1088. |
| MLA | Yu, Zhi-Xiang,et al."Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles".chemistry-an asian journal 5.5(2010):1072-1088. |
入库方式： OAI收割
来源：大连化学物理研究所
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