Classification and differential metabolite discovery of liver diseases based on plasma metabolic profiling and support vector machines
文献类型：期刊论文
| 作者 | Lin, Xiaohui2; Zhang, Yang2; Ye, Guozhu1; Li, Xiang1; Yin, Peiyuan1; Ruan, Qiang2; Xu, Guowang1 |
| 刊名 | journal of separation science
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 34期号:21页码:3029-3036 |
| 关键词 | Analysis of variance GC-MS Liver diseases Metabonomics Support vector machine |
| 英文摘要 | discovery of differential metabolites is the focus of metabonomics study. it has very important applications in pathogenesis and disease classification. the aim of this work is to identify differential metabolites for classifying the patients with hepatocellular carcinoma, cirrhosis and hepatitis based on metabolic profiling data analyzed by gas chromatography-time of flight mass spectrometry. a two-stage feature selection algorithm, f-svm, combining f-score in analysis of variance and support vector machine (svm), was applied in discovering discriminative metabolites for three different types of liver diseases. the results show that the accuracy rate of the double cross-validation was 73.68 +/- 2.98%. 22 important differential metabolites selected by f-svm were identified and related pathophysiological process of liver diseases was set forth. we conclude that f-svm is quite feasible to be applied in the selection of biologically relevant features in metabonomics. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | gas chromatography/mass spectrometry ; performance liquid-chromatography ; flight-mass-spectrometry ; hepatocellular-carcinoma ; feature-selection ; amino-acid ; gene-expression ; microarray data ; human urine ; gc-ms |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297415600014 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142281]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Dalian Univ Technol, Sch Comp Sci & Technol, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Xiaohui,Zhang, Yang,Ye, Guozhu,et al. Classification and differential metabolite discovery of liver diseases based on plasma metabolic profiling and support vector machines[J]. journal of separation science,2011,34(21):3029-3036. |
| APA | Lin, Xiaohui.,Zhang, Yang.,Ye, Guozhu.,Li, Xiang.,Yin, Peiyuan.,...&Xu, Guowang.(2011).Classification and differential metabolite discovery of liver diseases based on plasma metabolic profiling and support vector machines.journal of separation science,34(21),3029-3036. |
| MLA | Lin, Xiaohui,et al."Classification and differential metabolite discovery of liver diseases based on plasma metabolic profiling and support vector machines".journal of separation science 34.21(2011):3029-3036. |
入库方式： OAI收割
来源：大连化学物理研究所
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