Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative
文献类型：期刊论文
| 作者 | Zhang, Zhenjiang; He, Xiangwei; Yuan, Gu |
| 刊名 | international journal of biological macromolecules
 |
| 出版日期 | 2011-12-01 |
| 卷号 | 49期号:5页码:1173-1176 |
| 关键词 | G-quadruplex c-myc Pyrene derivatives Rational drug design Transcription control |
| 英文摘要 | it has been established that the equilibrium between duplex and g-quadruplex of the nuclease hypersensitivity element iii1 (nhe iii1) in human c-myc promoter is linked with this gene's transcription. using nmr and esi-ms, we have found a pyrene derivative, dmapp, is able to modulate this equilibrium and, thus, might have the potential to regulate this oncogene's transcription. dmapp has shown as a g-quadruplex binding agent and could induce c-myc g-quadruplex formation out of duplex. these results provide new clue for rational drug design to target transcription control of c-myc. (c) 2011 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | small-molecule ; in-vivo ; telomerase ; growth ; gene ; proliferation ; stabilization ; transcription ; stability ; porphyrin |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000296937200047 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142321]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhenjiang,He, Xiangwei,Yuan, Gu. Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative[J]. international journal of biological macromolecules,2011,49(5):1173-1176. |
| APA | Zhang, Zhenjiang,He, Xiangwei,&Yuan, Gu.(2011).Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative.international journal of biological macromolecules,49(5),1173-1176. |
| MLA | Zhang, Zhenjiang,et al."Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative".international journal of biological macromolecules 49.5(2011):1173-1176. |
入库方式： OAI收割
来源：大连化学物理研究所
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