Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry
文献类型：期刊论文
| 作者 | Cui, Xiaojie; Yuan, Gu |
| 刊名 | journal of mass spectrometry
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 46期号:9页码:849-855 |
| 关键词 | G-quadruplex c-myb gene ESI-MS dehydrocorydaline autodock |
| 英文摘要 | in this study, electrospray ionization mass spectrometry (esi-ms) is used to study the formation of g-quadruplex by d(ggaggaggagga) which locates at the promoter region of c-myb gene. in addition, a natural small molecule, dehydrocorydaline from a chinese herb, is found to have the highest binding affinity with the g-quadruplex in nine natural small molecules studied, and the binding selectivity of this natural molecule toward the c-myb g-quadruplex with respect to corresponding duplex dna is significantly higher than that of the broad-spectrum g-quadruplex-ligand tmpyp4. the result from esi-ms indicates that the gas-phase kinetic stability of the g-quadruplex can be enhanced by binding of dehydrocorydaline. to further investigate the binding properties of dehydrocorydaline to the g-quadruplex, autodock3 is used to calculate the docked sites and docked energies of small molecules binding to the g-quadruplex and the result shows that the docked energy of dehydrocorydaline is the biggest in the nine small molecules used, consistent with the result from esi-ms. copyright (c) 2011 john wiley & sons, ltd. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences ; technology |
| 类目[WOS] | biochemical research methods ; chemistry, analytical ; spectroscopy |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry ; spectroscopy |
| 关键词[WOS] | hiv-1 integrase inhibitors ; dimeric g-quadruplexes ; triplet repeat dna ; binding ; differentiation ; expression ; complexes ; leukemias ; gene ; therapeutics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000295723200001 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142324]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Xiaojie,Yuan, Gu. Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry[J]. journal of mass spectrometry,2011,46(9):849-855. |
| APA | Cui, Xiaojie,&Yuan, Gu.(2011).Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry.journal of mass spectrometry,46(9),849-855. |
| MLA | Cui, Xiaojie,et al."Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry".journal of mass spectrometry 46.9(2011):849-855. |
入库方式： OAI收割
来源：大连化学物理研究所
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