MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION
文献类型：期刊论文
| 作者 | Yuan, Gu1; Zhang, Qiang1; Zhou, Jiang1; Li, Huihui1,2 |
| 刊名 | mass spectrometry reviews
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 30期号:6页码:1121-1142 |
| 关键词 | mass spectrometry G-quadruplex DNA formation recognition conversion |
| 英文摘要 | g-quadruplexes are special secondary structures formed from g-rich sequences of dna, and have proven to play important roles in a number of biological systems, including the regulation of gene transcription and translation. the highly distinctive nature of g-quadruplex structures and their functions suggest that g-quadruplexes can act as novel targets for drug development. as a highly sensitive analytical tool, mass spectrometry has been widely used for the analysis of g-quadruplex structures. electrospray-ionization mass spectrometry, in particular, has found captivating applications to probe interactions between small molecules and g-quadruplex dna. in this review, we will discuss: (1) mass spectrometry probing of the formation, binding affinity, and stoichiometry between g-quadruplexes and small molecules; (2) stabilization and collision-dissociation behavior of g-quadruplex dna; (3) the exploration of the equilibrium transfer between a g-quadruplex and duplex dna; and (4) the esi-ms analysis of the conversion of intramolecular and intermolecular g-quadruplexes. finally, we will also introduce the application of new techniques in the analysis of g-quadruplex conformation, such as ion-mobility and infrared multiphoton-dissociation mass spectrometry. we believe that, with the new technical developments, mass spectrometry will play an unparalleled role in the analysis of the g-quadruplex structures. (c) 2011 wiley periodicals, inc., mass spec rev 30:1121-1142, 2011 |
| WOS标题词 | science & technology ; technology |
| 类目[WOS] | spectroscopy |
| 研究领域[WOS] | spectroscopy |
| 关键词[WOS] | human telomeric dna ; end-linked oligonucleotides ; intramolecular g-quadruplex ; hiv-1 integrase inhibitors ; thrombin-binding aptamer ; dimeric g-quadruplexes ; gas-phase ; promoter region ; c-myc ; guanine-quadruplexes |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297015700009 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142422]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Nanjing Normal Univ, Jiangsu Key Lab Biofunct Mat, Sch Chem & Environm Sci, Nanjing 210097, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Gu,Zhang, Qiang,Zhou, Jiang,et al. MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION[J]. mass spectrometry reviews,2011,30(6):1121-1142. |
| APA | Yuan, Gu,Zhang, Qiang,Zhou, Jiang,&Li, Huihui.(2011).MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION.mass spectrometry reviews,30(6),1121-1142. |
| MLA | Yuan, Gu,et al."MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION".mass spectrometry reviews 30.6(2011):1121-1142. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。