A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells under tensile stress
文献类型：期刊论文
| 作者 | Gao, Xinghua1; Zhang, Xu1; Tong, Huiyu2; Lin, Bingcheng1; Qin, Jianhua1 |
| 刊名 | electrophoresis
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 32期号:23页码:3431-3436 |
| 关键词 | Differentiation Mesenchymal stem cell Microfluidic Tensile stress |
| 英文摘要 | this work presents a simple membrane-based microfluidic chip for the investigation of proliferation and differentiation of mesenchymal stem cells (mscs) under mechanical stimuli. the cyclic tensile stress was generated by the deformation of elastic pdms membrane sandwiched between the two layer microfluidic chip via actuated negative pressure, and the cultured mscs on membrane were subjected to different orders of tensile stress. the results suggest that mechanical stimuli are attributed to the different phenomena of mscs in cell proliferation and differentiation. the higher tensile stress (>3.5) promoted obvious proliferation, osteogenesis and reduced adipogenesis in mscs, indicating the possible regulative role of tensile stress in modifying the osteogenesis/adipogenesis balance in the development of tissue organ. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | mechanical stimulation ; marrow ; force ; fate |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000298300900017 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142443]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Gen Hosp PLA, Dept Neurosurg, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Xinghua,Zhang, Xu,Tong, Huiyu,et al. A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells under tensile stress[J]. electrophoresis,2011,32(23):3431-3436. |
| APA | Gao, Xinghua,Zhang, Xu,Tong, Huiyu,Lin, Bingcheng,&Qin, Jianhua.(2011).A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells under tensile stress.electrophoresis,32(23),3431-3436. |
| MLA | Gao, Xinghua,et al."A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells under tensile stress".electrophoresis 32.23(2011):3431-3436. |
入库方式： OAI收割
来源：大连化学物理研究所
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