Identification of major metabolites in rat urine and plasma of N-6-(4-hydroxybenzyl) adenine riboside by LC/MS/MS
文献类型：期刊论文
| 作者 | Lei, Yujia; Wang, Li; Cheng, Mengchun; Xiao, Hongbin |
| 刊名 | biomedical chromatography
 |
| 出版日期 | 2011-03-01 |
| 卷号 | 25期号:3页码:344-352 |
| 关键词 | N-6-(4-hydroxybenzyl) adenine riboside Gastrodia elata metabolism metabolite identification LC/MS/MS |
| 英文摘要 | n-6-(4-hydroxybenzyl) adenine riboside, a novel neuroprotective compound found in gastrodia elata at trace level, is regarded as a potential drug for the treatment of neural degenerative disease. to understand the metabolism of this compound, the metabolites in rat urine and plasma of n-6-(4-hydroxybenzyl) adenine riboside were analyzed by hplc-esi-ms/ms after oral administration of this compound. beside the parent compound, six phase i metabolites and four phase ii metabolites in urine were detected by scanning all possible metabolites in extracted ion chromatograms mode. by comparing their product ion spectra and retention times with those of parent compound, these metabolites were identified and proved to be mainly formed via hydrolysis or hydroxylation in phase i, n-sulfation or n-glucuronidation in phase ii or their combinations. similarly, the parent compound, one phase i metabolite and two phase ii metabolites were also identified in rat plasma. therefore, the in vivo metabolic pathways of n-6-(4-hydroxybenzyl) adenine riboside in rat were proposed. copyright (c) 2010 johnwiley & sons, ltd. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; biochemistry & molecular biology ; chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | trap mass-spectrometry ; liquid-chromatography ; electrospray-ionization ; gastrodia-elata ; phase-i |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000288032100003 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142452]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Dalian Inst Chem Phys, Med Chem Lab, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Yujia,Wang, Li,Cheng, Mengchun,et al. Identification of major metabolites in rat urine and plasma of N-6-(4-hydroxybenzyl) adenine riboside by LC/MS/MS[J]. biomedical chromatography,2011,25(3):344-352. |
| APA | Lei, Yujia,Wang, Li,Cheng, Mengchun,&Xiao, Hongbin.(2011).Identification of major metabolites in rat urine and plasma of N-6-(4-hydroxybenzyl) adenine riboside by LC/MS/MS.biomedical chromatography,25(3),344-352. |
| MLA | Lei, Yujia,et al."Identification of major metabolites in rat urine and plasma of N-6-(4-hydroxybenzyl) adenine riboside by LC/MS/MS".biomedical chromatography 25.3(2011):344-352. |
入库方式： OAI收割
来源：大连化学物理研究所
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