Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene
文献类型：期刊论文
| 作者 | Lin, Sen2; Li, Sufang1; Chen, Zan1; He, Xiangwei1; Zhang, Youyi1; Xu, Xiaojie2; Xu, Ming1; Yuan, Gu2 |
| 刊名 | bioorganic & medicinal chemistry letters
 |
| 出版日期 | 2011-10-01 |
| 卷号 | 21期号:19页码:5987-5991 |
| 关键词 | G-Quadruplex 3'-Flanking region Cepharanthine STAT3 gene Gene regulation |
| 英文摘要 | g-quadruplexes have been proved to exist in 5'-untranslated region (5'-utr), promoter, intron and exon regions of many human genes. here we report an intramolecular g-quadruplex formed by a g-rich sequence in the 3'-flanking region of signal transducers and activators of transcription 3 (stat3) gene. the results showed that this g-rich sequence could affect the expression of stat3. when the stat3 g-quadruplex was stabilized by a novel non-planar ligand cepharanthine (cep), the decreased expression of stat3 was observed in primary cultured cardiomyocytes. we also demonstrated that the down-regulation of stat3 was most likely occurred at the transcriptional level. our results provide a new clue for studying the g-quadruplex formation, recognition and function in the 3'-flanking region of gene. (c) 2011 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | chemistry, medicinal ; chemistry, organic |
| 研究领域[WOS] | pharmacology & pharmacy ; chemistry |
| 关键词[WOS] | circular-dichroism ; mass-spectrometry ; telomeric dna ; tumor-cells ; binding ; stabilization ; inhibition ; mechanisms ; conversion ; tetraplex |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000294714400071 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142478]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Peking Univ, Inst Vasc Med, Hosp 3, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100191, Peoples R China 2.Peking Univ, Beijing Natl Lab Mol Sci BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Sen,Li, Sufang,Chen, Zan,et al. Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene[J]. bioorganic & medicinal chemistry letters,2011,21(19):5987-5991. |
| APA | Lin, Sen.,Li, Sufang.,Chen, Zan.,He, Xiangwei.,Zhang, Youyi.,...&Yuan, Gu.(2011).Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene.bioorganic & medicinal chemistry letters,21(19),5987-5991. |
| MLA | Lin, Sen,et al."Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene".bioorganic & medicinal chemistry letters 21.19(2011):5987-5991. |
入库方式： OAI收割
来源：大连化学物理研究所
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