Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS
文献类型：期刊论文
| 作者 | Zuo, Aihua1; Wang, Li1; Xiao, Hongbin1; Li, Limin2; Liu, Yuhong2; Yi, Jinhai2 |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2011-12-15 |
| 卷号 | 56期号:5页码:1046-1056 |
| 关键词 | Absorbed components HPLC-ESI-MS Rat plasma Ligusticum chuanxiong Metabolism |
| 英文摘要 | an hplc-esi-ms/ms method was established to identify the absorbed components and metabolites in rat plasma after oral administration of rhizoma chuanxiong decoction (rcd), a well-known traditional chinese medicine. by comparing the extracted ion chromatograms (eics) obtained from dosed rat plasma, blank rat plasma and rcd, a total of 25 compounds were detected in dosed rat plasma. among them, 13 compounds were absorbed into rat plasma in prototype and identified as ferulic acid, senkyunolide j, senkyunolide i, senkyunolide d or 4,7-dihydroxy-3-butylphthalide, senkyunolide f, senkyunolide m, senkyunolide q senkyunolide a, e-butylidenephthalide, e-ligustilide, neocnidilide, z-ligustilide, levistolide a, according to the retention times, uv, ms, ms/ms spectra. in addition, 12 conjugated metabolites including 6 senkyunolide i-related metabolites, 4 senkyunolide j-related metabolites and 2 butylidenephthalide-related metabolites were also detected and identified by comparing their ms, ms/ms spectra with that of corresponding original components. conjugated with glutathione, cysteine, glucuronic acid and sulphuric acid were the main metabolic reactions of phthalides. finally the in vivo metabolic pathways of chemical constituents of chuanxiong in rat plasma were proposed in this study. (c) 2011 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | chromatography-mass spectrometry ; major bioactive component ; ligusticum-chuanxiong ; constituents ; pharmacokinetics ; senkyunolide ; derivatives ; mouse ; aorta |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000295304100026 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142501]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Sichuan Acad Chinese Med Sci, Chengdu 610041, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zuo, Aihua,Wang, Li,Xiao, Hongbin,et al. Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS[J]. journal of pharmaceutical and biomedical analysis,2011,56(5):1046-1056. |
| APA | Zuo, Aihua,Wang, Li,Xiao, Hongbin,Li, Limin,Liu, Yuhong,&Yi, Jinhai.(2011).Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS.journal of pharmaceutical and biomedical analysis,56(5),1046-1056. |
| MLA | Zuo, Aihua,et al."Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS".journal of pharmaceutical and biomedical analysis 56.5(2011):1046-1056. |
入库方式： OAI收割
来源：大连化学物理研究所
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