Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry
文献类型：期刊论文
| 作者 | Zhou, Zhigui; Zhang, Jialing; Zhang, Wei; Bai, Yu; Liu, Huwei |
| 刊名 | analyst
 |
| 出版日期 | 2011 |
| 卷号 | 136期号:12页码:2613-2618 |
| 英文摘要 | adulteration of herbal supplements with synthetic drugs is illegal. a rapid and reliable method which utilizes direct analysis in real time mass spectrometry (dart-ms) was developed for the identification of seven synthetic antidiabetic drugs used as adulterants in herbal dietary supplements. the supplement sample was simply extracted with methanol/water by manually shaking several times and directly analyzed using dart-ms. the presence of synthetic drug adulterants was confirmed through the accurate m/z values and ms/ms data obtained via quadruple time of flight mass spectrometry (qtof ms). parameters for the dart source were systematically optimized, and the limits of detection (lods) in herbal supplement matrices were measured. this method was successfully applied to examine five commercial herbal dietary supplements, and two of them proved to be adulterated with metformin without labeling. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | performance liquid-chromatography ; human plasma ; electrospray-ionization ; sulfonylurea-type ; ion-source ; metformin ; quantification ; identification ; rosiglitazone ; glibenclamide |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000291164900025 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142559]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Coll Chem & Mol Engn,Inst Analyt Chem,Minist Educ, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Zhigui,Zhang, Jialing,Zhang, Wei,et al. Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry[J]. analyst,2011,136(12):2613-2618. |
| APA | Zhou, Zhigui,Zhang, Jialing,Zhang, Wei,Bai, Yu,&Liu, Huwei.(2011).Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry.analyst,136(12),2613-2618. |
| MLA | Zhou, Zhigui,et al."Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry".analyst 136.12(2011):2613-2618. |
入库方式： OAI收割
来源：大连化学物理研究所
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