Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib
文献类型：期刊论文
| 作者 | Dong, Pei-pei1,2; Fang, Zhong-ze1,2; Zhang, Yan-yan1; Ge, Guang-bo1; Mao, Yu-xi1,2; Zhu, Liang-liang1,2; Qu, Yan-qing3; Li, Wei1,2; Wang, Li-ming3; Liu, Chang-xiao4 |
| 刊名 | acta pharmacologica sinica
 |
| 出版日期 | 2011-03-01 |
| 卷号 | 32期号:3页码:399-407 |
| 关键词 | erlotinib CYP isoform human liver microsomes substrate-dependent inhibition (or modulation) drug interaction |
| 英文摘要 | aim: to ascertain the effects of erlotinib on cyp3a, to investigate the amplitude and kinetics of erlotinib-mediated inhibition of seven major cyp isoforms in human liver microsomes (hlms) for evaluating the magnitude of erlotinib in drug-drug interaction in vivo. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, multidisciplinary ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | human cytochrome-p450 enzymes ; drug-drug interactions ; cell lung-cancer ; receptor tyrosine kinase ; advanced solid tumors ; in-vitro data ; liver-microsomes ; phase-i ; metabolism ; inhibition |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000288003200017 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142569]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Dalian Med Univ, Affiliated Hosp 2, Dalian 116027, Peoples R China 4.Tianjin Inst Pharmaceut Res, Tianjin Key Lab Pharmacokinet & Clin Pharmacol, Tianjin 300193, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Pei-pei,Fang, Zhong-ze,Zhang, Yan-yan,et al. Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib[J]. acta pharmacologica sinica,2011,32(3):399-407. |
| APA | Dong, Pei-pei.,Fang, Zhong-ze.,Zhang, Yan-yan.,Ge, Guang-bo.,Mao, Yu-xi.,...&Yang, Ling.(2011).Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib.acta pharmacologica sinica,32(3),399-407. |
| MLA | Dong, Pei-pei,et al."Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib".acta pharmacologica sinica 32.3(2011):399-407. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。