A New Class of Structurally Rigid Tricyclic Chiral Secondary Amine Organocatalyst: Highly Enantioselective Organocatalytic Michael Addition of Aldehydes to Vinyl Sulfones
文献类型：期刊论文
| 作者 | Xiao, Jian1,2; Lu, Yun-Peng1; Liu, Yan-Ling1; Wong, Poh-Shen1; Loh, Teck-Peng1 |
| 刊名 | organic letters
 |
| 出版日期 | 2011-03-04 |
| 卷号 | 13期号:5页码:876-879 |
| 英文摘要 | a new class of chiral secondary amine organocatalyst was rationally designed as an efficient catalyst to catalyze the elusive michael addition of aldehydes to vinyl sulfones. high yield and excellent enantioselectivities could be obtained at room temperature without having to resort to high catalyst loading, anhydrous solvents, and low temperatures. efficient control of enamine conformation and face shielding as well as the rigid nature of the tricyclic skeleton, with an inherent chiral pocket, provide a well-organized chiral environment to effect this elusive reaction efficiently. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, organic |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | asymmetric aldol reactions ; intermolecular alpha-alkylation ; bond-forming reactions ; conjugate additions ; enamine catalysis ; cinchona alkaloids ; organic catalysis ; mannich reactions ; natural-product ; design |
| 收录类别 | SCI ; IC ; CCR |
| 语种 | 英语 |
| WOS记录号 | WOS:000287645800014 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142590]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Jian,Lu, Yun-Peng,Liu, Yan-Ling,et al. A New Class of Structurally Rigid Tricyclic Chiral Secondary Amine Organocatalyst: Highly Enantioselective Organocatalytic Michael Addition of Aldehydes to Vinyl Sulfones[J]. organic letters,2011,13(5):876-879. |
| APA | Xiao, Jian,Lu, Yun-Peng,Liu, Yan-Ling,Wong, Poh-Shen,&Loh, Teck-Peng.(2011).A New Class of Structurally Rigid Tricyclic Chiral Secondary Amine Organocatalyst: Highly Enantioselective Organocatalytic Michael Addition of Aldehydes to Vinyl Sulfones.organic letters,13(5),876-879. |
| MLA | Xiao, Jian,et al."A New Class of Structurally Rigid Tricyclic Chiral Secondary Amine Organocatalyst: Highly Enantioselective Organocatalytic Michael Addition of Aldehydes to Vinyl Sulfones".organic letters 13.5(2011):876-879. |
入库方式： OAI收割
来源：大连化学物理研究所
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