Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases
文献类型：期刊论文
| 作者 | Liu, Kun-hui; Wu, Li-dan; Zou, Xiao-ran; Yang, Wen; Du, Qian; Su, Hong-mei |
| 刊名 | chinese journal of chemical physics
 |
| 出版日期 | 2011-10-01 |
| 卷号 | 24期号:5页码:580-585 |
| 关键词 | Tetrachlorobenzoquinone Thymine Uracil Triplet state Hydrogen abstraction Electron transfer Laser flash photolysis |
| 英文摘要 | pentachlorophenol, a widespread environmental pollutant that is possibly carcinogenic to humans, is metabolically oxidized to tetrachloroquinone (tcbq) which can result in dna damage. we have investigated the photochemical. reaction dynamics of tcbq with two pyrimidine type nucleobases (thymine and uracil) upon uva (355 nm) excitation using the technique of nanosecond time-resolved laser flash photolysis. it has been found that 355 nm excitation populates tcbq molecules to their triplet state (3)tcbq*, which are highly reactive towards thymine or uracil and undergo two parallel reactions, the hydrogen abstraction and electron transfer, leading to the observed photoproducts of tcbqh. and tcbq.(-) in transient absorption spectra. the concomitantly produced nucleobase radicals and radical cations are expected to induce a series of oxidative or strand cleavage damage to dna afterwards. by characterizing the photochemical hydrogen abstraction and electron transfer reactions, our results provide potentially important molecular reaction mechanisms for understanding the carcinogenic effects of pentachlorophenol and its metabolites tcbq. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | physics, atomic, molecular & chemical |
| 研究领域[WOS] | physics |
| 关键词[WOS] | laser flash-photolysis ; radical cations ; triplet-state ; dna ; pentachlorophenol ; chloranil ; quinones ; guanine ; carcinogenesis ; toxicology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297139200012 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142639]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, State Key Lab Mol React Dynam, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Kun-hui,Wu, Li-dan,Zou, Xiao-ran,et al. Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases[J]. chinese journal of chemical physics,2011,24(5):580-585. |
| APA | Liu, Kun-hui,Wu, Li-dan,Zou, Xiao-ran,Yang, Wen,Du, Qian,&Su, Hong-mei.(2011).Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases.chinese journal of chemical physics,24(5),580-585. |
| MLA | Liu, Kun-hui,et al."Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases".chinese journal of chemical physics 24.5(2011):580-585. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。