Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-alpha in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways
文献类型：期刊论文
| 作者 | Ma, Pan1,2; Liu, Hong-Tao1; Wei, Peng1,2; Xu, Qing-Song1; Bai, Xue-Fang1; Du, Yu-Guang1; Yu, Chao3 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2011-04-02 |
| 卷号 | 84期号:4页码:1391-1398 |
| 关键词 | Chitosan oligomers Inflammation Mitogen-activated protein kinase Phosphatidylinositol 3-kinase Macrophage cells |
| 英文摘要 | chitosan oligomers show various biological activities. however, its molecular mechanisms remain unknown in lps-stimulated macrophages. here, we explored the inhibitive effects of chitosan oligomers on lps-induced il-6/tnf-alpha production in macrophages. the results indicated chitosan oligomers pretreatment effectively inhibited lps-induced over-expression of both inflammatory cytokines. signal transduction studies show chitosan oligomers may repress not only the phosphorylation of p38, erk1/2, jnk, phosphatidylinositol 3-kinase (pi3k) and akt, but also the activation of nuclear factor-kappa b (nf-kappa b) and activator protein-1 (ap-1). furthermore, both the activation of nf-kappa b/ap-1 and the subsequent il-6/tnf-alpha over-expression in lps-induced macrophages are inhibited by specific p38 inhibitor (sb203580), erk1/2 inhibitor (pd98059), jnk inhibitor (sp600125) and pi3k inhibitor (ly294002). in conclusion, our investigation suggests chitosan oligomers inhibited the elevated expression of il-6/tnf-alpha in lps-induced macrophages, regulated by mapks and pi3k/akt pathways dependent on nf-kappa b/ap-1 activation. (c) 2011 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | nf-kappa-b ; tumor-necrosis-factor ; gene-expression ; endothelial-cells ; induced cytokine ; chitooligosaccharides ; p38 ; inflammation ; phosphorylation ; inactivation |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000289123300026 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142644]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 110864, Peoples R China 3.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Pan,Liu, Hong-Tao,Wei, Peng,et al. Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-alpha in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways[J]. carbohydrate polymers,2011,84(4):1391-1398. |
| APA | Ma, Pan.,Liu, Hong-Tao.,Wei, Peng.,Xu, Qing-Song.,Bai, Xue-Fang.,...&Yu, Chao.(2011).Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-alpha in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways.carbohydrate polymers,84(4),1391-1398. |
| MLA | Ma, Pan,et al."Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-alpha in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways".carbohydrate polymers 84.4(2011):1391-1398. |
入库方式： OAI收割
来源：大连化学物理研究所
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