A convenient method for synthesis of tetraoxazole peptide macrocycles
文献类型：期刊论文
| 作者 | Zhang, Zhenjiang; Yuan, Gu |
| 刊名 | arkivoc
 |
| 出版日期 | 2011 |
| 页码 | 368-378 |
| 关键词 | G-quadruplex poly-oxazole anticancer drug discovery macrocyclization peptide |
| 英文摘要 | g-quadruplex dna plays important regulatory roles in the maintenance of telomere length and transcriptions inhibition of such oncogenes as c-myc, and thus has become an attractive target for the development of anti-cancer therapeutic agents. poly-oxazole macrocycles are a promising new class of g-quadruplex binding ligands. herein is described the synthesis of a tetraoxazole peptide macrocycle and an epimerization product. the synthetic unit was prepared by cyclization-oxidation of a diserine with one hydroxyl protected. two-cycle coupling of the unit gave a linear tetraoxazole amide. the targeted molecule and the epimerization product were obtained after macrocyclization of the linear precursor and following removal of the protecting benzyl groups. with structural similarities to the most potent g-quadruplex stabilizer telomestatin, these two molecules might potentially be used to probe the biological significance of g-quadruplex' in vivo. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, organic |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | quadruplex stabilizing properties ; methylated amino-acids ; telomerase inhibitor ; trifluoride dast ; telomestatin ; reagent ; oxazolines |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297767300030 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142695]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Dept Chem Biol ,Coll Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhenjiang,Yuan, Gu. A convenient method for synthesis of tetraoxazole peptide macrocycles[J]. arkivoc,2011:368-378. |
| APA | Zhang, Zhenjiang,&Yuan, Gu.(2011).A convenient method for synthesis of tetraoxazole peptide macrocycles.arkivoc,368-378. |
| MLA | Zhang, Zhenjiang,et al."A convenient method for synthesis of tetraoxazole peptide macrocycles".arkivoc (2011):368-378. |
入库方式： OAI收割
来源：大连化学物理研究所
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