Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia glutinosa Roots
文献类型：期刊论文
| 作者 | Chang, Wen-Te1; Choi, Young Hae2; Van der Heijden, Rob3; Lee, Meng-Shiou1; Lin, Ming-Kuem1; Kong, Hongwei3,4; Kim, Hye Kyong2; Verpoorte, Robert2; Hankemeier, Thomas3; Van der Greef, Jan3,5 |
| 刊名 | chemical & pharmaceutical bulletin
 |
| 出版日期 | 2011-05-01 |
| 卷号 | 59期号:5页码:546-552 |
| 关键词 | Rehmannia glutinosa traditional processing Fourier-transform-mass spectrometry principle component analysis |
| 英文摘要 | the processing of biological raw materials is considered to have an important role in the therapeutic application in traditional chinese medicine. the root of rehmannia glutinosa has to be processed by nine cycles of rice wine immersing, steaming and drying before using in clinical applications. in order to understand the chemical changes resulting from the processing, a comprehensive analysis of rehmanniae radix was made using h-1-nmr and fourier transform (ft)-mass spectrometry in combination with multivariate data analysis. after h-1-nmr and principle component analysis, hydrolysis was found to be the major chemical process during the treatments. catalpol, raffinose and stachyose levels gradually decreased during processing, whereas monosaccharides including galactose and glucose were found to be higher in processed roots. the metabolic profile changed gradually through the processing cycles although the differences became smaller after the fifth processing cycle. the positive and negative ion-mode mass spectra by high resolution ft-ms revealed several series of ion clusters with mass differences of 162.053 da, indicating a difference of a hexose moiety. during the processing, the number and signal intensity of the smaller glycosides were increased. therefore, these results indicate that the fresh rehmanniae radix is rich in polysaccharides, which are hydrolyzed during the processing. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | chemistry, medicinal ; chemistry, multidisciplinary ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy ; chemistry |
| 关键词[WOS] | nuclear-magnetic-resonance ; absolute stereostructures ; iridoid glycosides ; quality-control ; diabetic-rats ; radix ; spectroscopy ; constituents ; libosch ; polysaccharides |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000290194400004 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142729]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.China Med Univ, Sch Chinese Med Resources, Taichung 40402, Taiwan 2.Leiden Univ, Inst Biol, Sect Metabol, Div Pharmacognosy, NL-2300 RA Leiden, Netherlands 3.Leiden Amsterdam Ctr Drug Res, Ctr Med Syst Biol, Div Analyt Biosci, NL-2300 RA Leiden, Netherlands 4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China 5.SU BioMed, NL-3700 AJ Zeist, Netherlands 6.TNO Qual Life, Dept Appl Plant Sci, NL-2333 CK Leiden, Netherlands |
| 推荐引用方式 GB/T 7714 | Chang, Wen-Te,Choi, Young Hae,Van der Heijden, Rob,et al. Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia glutinosa Roots[J]. chemical & pharmaceutical bulletin,2011,59(5):546-552. |
| APA | Chang, Wen-Te.,Choi, Young Hae.,Van der Heijden, Rob.,Lee, Meng-Shiou.,Lin, Ming-Kuem.,...&Wang, Mei.(2011).Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia glutinosa Roots.chemical & pharmaceutical bulletin,59(5),546-552. |
| MLA | Chang, Wen-Te,et al."Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia glutinosa Roots".chemical & pharmaceutical bulletin 59.5(2011):546-552. |
入库方式： OAI收割
来源：大连化学物理研究所
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