Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro
文献类型：期刊论文
| 作者 | Wei, Peng1,2; Ma, Pan1,2; Xu, Qing-Song1; Bai, Qun-Hua3; Gu, Jian-Guo4; Xi, Hao5; Du, Yu-Guang1; Yu, Chao3 |
| 刊名 | glycoconjugate journal
 |
| 出版日期 | 2012-08-01 |
| 卷号 | 29期号:5-6页码:285-295 |
| 关键词 | Chitosan oligosaccharides Microglial cell Inflammation MAPKs NF-kappa B AP-1 |
| 英文摘要 | chitosan oligosaccharides (cos) have been reported to exert many biological activities, such as antioxidant, antitumor and anti-inflammatory effects. in the present study, we examined the effect of cos on nitric oxide (no) production in lps induced n9 microglial cells. pretreatment with cos (50 similar to 200 mu g/ml) could markedly inhibit no production by suppressing inducible nitric oxide synthase (inos) expression in activated microglial cells. signal transduction studies showed that cos remarkably inhibited lps-induced phosphorylation of p38 mapk and erk1/2. cos pretreatment could also inhibit the activation of both nuclear factor-kappa b (nf-kappa b) and activator protein-1 (ap-1). in conclusion, our results suggest that cos could suppress the production of no in lps-induced n9 microglial cells, mediated by p38 mapk and erk1/2 pathways. |
| 类目[WOS] | biochemistry & molecular biology |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | activated protein-kinases ; signaling pathways ; mannose receptor ; map kinase ; c-fos ; expression ; inhibition ; p38 ; chitooligosaccharides ; complex |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000307763900006 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142876]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 110864, Peoples R China 3.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China 4.Tohoku Pharmaceut Univ, Div Regulatory Glycobiol, Inst Mol Biomembrane & Glycobiol, Sendai, Miyagi 9818558, Japan 5.Sichuan Univ, Chengdu 610064, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Peng,Ma, Pan,Xu, Qing-Song,et al. Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro[J]. glycoconjugate journal,2012,29(5-6):285-295. |
| APA | Wei, Peng.,Ma, Pan.,Xu, Qing-Song.,Bai, Qun-Hua.,Gu, Jian-Guo.,...&Yu, Chao.(2012).Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro.glycoconjugate journal,29(5-6),285-295. |
| MLA | Wei, Peng,et al."Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide-induced N9 murine microglial cells in vitro".glycoconjugate journal 29.5-6(2012):285-295. |
入库方式： OAI收割
来源：大连化学物理研究所
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