URINARY FATTY ACID COMPOSITION AND BIOMARKERS DISCOVERY FOR TYPE 2 DIABETIC PATIENTS BASED ON ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY-QUADRUPOLE/TIME OF FLIGHT MASS SPECTROMETRY AND MULTIVARIATE STATISTICAL ANALYSIS
文献类型：期刊论文
| 作者 | Xu, Wenjuan1; Zhang, Liangxiao1; Huang, Yuhong2; Yang, Qianxu1; Xiao, Hongbin1; Zhang, Deqin2 |
| 刊名 | analytical letters
 |
| 出版日期 | 2012 |
| 卷号 | 45期号:18页码:2649-2662 |
| 关键词 | Biomarker Diabetes mellitus Quadrupole time of flight mass spectrometry (Q-TOF/MS) Urine fatty acids |
| 英文摘要 | a strategy of high sensitive assay method of urine fatty acid profiles was established based on ultra-performance liquid chromatography-quadrupole time of flight-mass spectrometry (uplc/q-tof) and applied in metabolomics research of diabetes mellitus. in this way, 19 fatty acids including two pair of hard-resolved isomers were separated well in only 13 minutes, and q-tof mass spectrometry reduced the matrix interference of urine samples by high resolution and accurate molecular weights. under the optimal conditions, fatty acid profiles of 93 cases of urine samples were analyzed. fatty acid profiles of type 2 diabetes mellitus showed large differences from health controls based on multivariate data analysis; c16:0, c18:0, c18:2, c20:5, and c22:6 were screened as potential clinical biomarkers. this work is complementary to the clinical diagnosis of diabetes mellitus; additionally, noninvasive testing of urine samples made it more convenient for examination while reducing the patient's pain and improving their living conditions. |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | quantitative-determination ; mellitus ; plasma ; metabolomics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000311702900001 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142883]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Wenjuan,Zhang, Liangxiao,Huang, Yuhong,et al. URINARY FATTY ACID COMPOSITION AND BIOMARKERS DISCOVERY FOR TYPE 2 DIABETIC PATIENTS BASED ON ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY-QUADRUPOLE/TIME OF FLIGHT MASS SPECTROMETRY AND MULTIVARIATE STATISTICAL ANALYSIS[J]. analytical letters,2012,45(18):2649-2662. |
| APA | Xu, Wenjuan,Zhang, Liangxiao,Huang, Yuhong,Yang, Qianxu,Xiao, Hongbin,&Zhang, Deqin.(2012).URINARY FATTY ACID COMPOSITION AND BIOMARKERS DISCOVERY FOR TYPE 2 DIABETIC PATIENTS BASED ON ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY-QUADRUPOLE/TIME OF FLIGHT MASS SPECTROMETRY AND MULTIVARIATE STATISTICAL ANALYSIS.analytical letters,45(18),2649-2662. |
| MLA | Xu, Wenjuan,et al."URINARY FATTY ACID COMPOSITION AND BIOMARKERS DISCOVERY FOR TYPE 2 DIABETIC PATIENTS BASED ON ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY-QUADRUPOLE/TIME OF FLIGHT MASS SPECTROMETRY AND MULTIVARIATE STATISTICAL ANALYSIS".analytical letters 45.18(2012):2649-2662. |
入库方式： OAI收割
来源：大连化学物理研究所
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