Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
文献类型：期刊论文
| 作者 | Liu, Rong1,2; Lai, Yusi1; He, Bin1; Li, Yuan1; Wang, Gang1; Chang, Shuang1; Gu, Zhongwei1 |
| 刊名 | international journal of nanomedicine
 |
| 出版日期 | 2012 |
| 卷号 | 7页码:5249-5258 |
| 关键词 | polyrotaxane self-assembly nanoparticle doxorubicin supermolecular |
| 英文摘要 | a new approach of fabricating supramolecular nanoparticles generated by self-assembly polyrotaxanes for antitumor drug delivery has been reported. cinnamic-acid-modified poly(ethylene glycol) chains were threaded in alpha-cyclodextrins to form polyrotaxanes. the polyrotaxanes self-assembled supramolecular nanoparticles. the morphology of the nanoparticles was changed from nanovesicle to micelle after the antitumor drug, doxorubicin, was loaded. the release profile of the drug-loaded nanoparticles was investigated, and it was found that the sustaining release time could last for 32 hours. the drug-loaded nanoparticles were co-cultured with mouse 4t1 breast cancer cells with a drug concentration of 10 mu g/ml; the cell survival rate was 3.3% after a 72-hour incubation. in an in vivo study of breast cancer in a mouse model, the drug-loaded nanoparticles were injected in the tail veins of mice with a dose of 5 mg/kg body weight. the tumor inhibition rate of drug-loaded nanoparticles was 53%, which was better than that of doxorubicin hydrochloride. the cardiac toxicity of doxorubicin was decreased greatly after the encapsulation into supramolecular polyrotaxane nanoparticles. |
| 类目[WOS] | nanoscience & nanotechnology ; pharmacology & pharmacy |
| 研究领域[WOS] | science & technology - other topics ; pharmacology & pharmacy |
| 关键词[WOS] | alpha-cyclodextrin ; poly(ethylene glycol) ; inclusion complexes ; polymeric micelles ; gene delivery ; in-vivo ; doxorubicin ; tumor ; guest ; cancer |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309445600001 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142884]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Rong,Lai, Yusi,He, Bin,et al. Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery[J]. international journal of nanomedicine,2012,7:5249-5258. |
| APA | Liu, Rong.,Lai, Yusi.,He, Bin.,Li, Yuan.,Wang, Gang.,...&Gu, Zhongwei.(2012).Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery.international journal of nanomedicine,7,5249-5258. |
| MLA | Liu, Rong,et al."Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery".international journal of nanomedicine 7(2012):5249-5258. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。