Biological, Chemical, and Omics Research of Taxus Medicinal Resources
文献类型：期刊论文
| 作者 | Hao, Da-Cheng1; Xiao, Pei-Gen1,2; Ge, Guang-Bo3; Liu, Ming1 |
| 刊名 | drug development research
 |
| 出版日期 | 2012-12-01 |
| 卷号 | 73期号:8页码:477-486 |
| 关键词 | Taxus medicinal resource phylogeny and evolution biotechnology phytochemistry omics |
| 英文摘要 | taxus is a botanical source for the anticancer drug taxol (paclitaxel), first reported in 1971 as a result of bioassay guided fractionation of active extracts from stem bark samples of t. brevifolia. this led to additional discoveries of pharmacologically active taxoids in other taxus species and to investigations on their biosynthetic precursors, analogues, and derivatives. in continuation with our studies on taxus biochemistry, we review the genomics, transcriptomics, proteomics, metabolomics, and bioinformatics of taxus and their endophytic fungi. the bibliometric method is used to quantify and characterize the global scientific effort in the omics technologies being applied. we conclude that systems biology and omics technologies will play an increasingly important role in future medical research involving bioactive compounds of taxus and other natural products. drug dev res 73 : 477-486, 2012. (c) 2012 wiley periodicals, inc. |
| 类目[WOS] | chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy |
| 关键词[WOS] | positive darwinian selection ; ionization mass-spectrometry ; cell-suspension cultures ; methyl jasmonate ; molecular evolution ; transcriptome analysis ; taxane production ; natural-products ; cuspidata cells ; chinese yew |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000314221100003 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142921]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Jiaotong Univ, Biotechnol Inst, Sch Environm, Dalian, Peoples R China 2.Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hao, Da-Cheng,Xiao, Pei-Gen,Ge, Guang-Bo,et al. Biological, Chemical, and Omics Research of Taxus Medicinal Resources[J]. drug development research,2012,73(8):477-486. |
| APA | Hao, Da-Cheng,Xiao, Pei-Gen,Ge, Guang-Bo,&Liu, Ming.(2012).Biological, Chemical, and Omics Research of Taxus Medicinal Resources.drug development research,73(8),477-486. |
| MLA | Hao, Da-Cheng,et al."Biological, Chemical, and Omics Research of Taxus Medicinal Resources".drug development research 73.8(2012):477-486. |
入库方式： OAI收割
来源：大连化学物理研究所
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