Preparation and characterization of neutral poly(ethylene glycol) methacrylate-based monolith for normal phase liquid chromatography
文献类型：期刊论文
| 作者 | Li, Yun1; Lee, Milton L.2; Jin, Jing1; Chen, Jiping1 |
| 刊名 | talanta
 |
| 出版日期 | 2012-09-15 |
| 卷号 | 99页码:91-98 |
| 关键词 | Polymeric monoliths Poly(ethylene glycol) methacrylate Normal phase liquid chromatography Hydrophilic Dual retention capability |
| 英文摘要 | a novel porous poly(ethylene glycol) methacrylate-based monolithic column for normal phase liquid chromatography was prepared by thermally initiated polymerization of poly(ethylene glycol) methyl ether methacrylate (pegmema) and ethylene dimethacrylate (edma) in the presence of selected porogens. the monolith was macroscopically homogeneous, had low flow resistance, and did not swell or shrink significantly in solvents of different polarities. inverse size-exclusion data indicate that the monolith had a total porosity of 79.2%, including an external porosity of 69.3% and an internal porosity of 9.9%. due to its mild polarity (hydrophilicity), the peg-functionalized monolith could perform traditional normal phase chromatography using non-polar solvents the van deemter plot demonstrated that the column efficiency of 33,600-34,320 theoretical plates/m could be achieved at a linear flow velocity of 0.9-1.5 mm/s. the dual retention capability (both weak hydrophilic and hydrophobic interactions) investigated in this paper explains well why the peg-functionalized monolith could operate in various chromatographic modes. (c) 2012 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | capillary electrochromatography ; polymer monoliths ; mass-spectrometry ; stationary phases ; separation media ; silica columns ; hplc ; peptides ; acids ; rods |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309785300013 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142969]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Liaoning, Peoples R China 2.Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA |
| 推荐引用方式 GB/T 7714 | Li, Yun,Lee, Milton L.,Jin, Jing,et al. Preparation and characterization of neutral poly(ethylene glycol) methacrylate-based monolith for normal phase liquid chromatography[J]. talanta,2012,99:91-98. |
| APA | Li, Yun,Lee, Milton L.,Jin, Jing,&Chen, Jiping.(2012).Preparation and characterization of neutral poly(ethylene glycol) methacrylate-based monolith for normal phase liquid chromatography.talanta,99,91-98. |
| MLA | Li, Yun,et al."Preparation and characterization of neutral poly(ethylene glycol) methacrylate-based monolith for normal phase liquid chromatography".talanta 99(2012):91-98. |
入库方式： OAI收割
来源：大连化学物理研究所
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