A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities
文献类型：期刊论文
| 作者 | He, Min1,2; Guan, Ni2; Gao, Wei-wei1; Liu, Qing1,2; Wu, Xiao-yan1; Ma, Da-wei3; Zhong, Da-fang2; Ge, Guang-bo4; Li, Chuan2; Chen, Xiao-yan2 |
| 刊名 | acta pharmacologica sinica
 |
| 出版日期 | 2012-02-01 |
| 卷号 | 33期号:2页码:148-154 |
| 关键词 | type 2 diabetes glucagon-like peptide-1 non-peptidic agonist Boc5 G-protein coupled receptor |
| 英文摘要 | glucagon-like peptide-1 (glp-1)-based therapy presents a promising option for treating type 2 diabetes. however, there are several limitations relative to the peptidic glp-1 mimetics currently on the market or under development. this concern has led to a continued interest in the search for non-peptidic agonists for glp-1 receptor (glp-1r). here, we briefly review the discovery, characterization and current status of a novel class of cyclobutane-derivative-based non-peptidic agonists for glp-1r, including boc5 and its newly discovered analogue wb4-24. although the oral bioavailability of such compounds still poses great challenges, the progress made so far encourages us to identify a truly 'druggable' small molecule agonist for glp-1r. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, multidisciplinary ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | protein-coupled receptor ; glycemic control ; exenatide exendin-4 ; crystal-structure ; treated patients ; weight ; sulfonylurea ; secretion ; metformin ; efficacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000300255400002 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/142989]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 5.Univ Calif Riverside, Dept Bioengn, Riverside, CA 92521 USA |
| 推荐引用方式 GB/T 7714 | He, Min,Guan, Ni,Gao, Wei-wei,et al. A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities[J]. acta pharmacologica sinica,2012,33(2):148-154. |
| APA | He, Min.,Guan, Ni.,Gao, Wei-wei.,Liu, Qing.,Wu, Xiao-yan.,...&Wang, Ming-wei.(2012).A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities.acta pharmacologica sinica,33(2),148-154. |
| MLA | He, Min,et al."A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities".acta pharmacologica sinica 33.2(2012):148-154. |
入库方式： OAI收割
来源：大连化学物理研究所
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