Click chemistry: a new facile and efficient strategy for the preparation of Fe3O4 nanoparticles covalently functionalized with IDA-Cu and their application in the depletion of abundant protein in blood samples
文献类型：期刊论文
| 作者 | Jian, Guiqin1,2; Liu, Yuxing1,2; He, Xiwen1,2; Chen, Langxing1,2; Zhang, Yukui1,2,3 |
| 刊名 | nanoscale
 |
| 出版日期 | 2012 |
| 卷号 | 4期号:20页码:6336-6342 |
| 英文摘要 | in this study, we report a novel method to synthesize core-shell structured fe3o4 nanoparticles (nps) covalently functionalized with iminodiacetic acid (ida) via click chemistry between the azide and alkyne groups and charged with cu2+. firstly, the fe3o4@sio2 nps were obtained using tetraethoxysilane (teos) to form a silica shell on the surface of the fe3o4 core. the azide group-modified fe3o4@sio2 nps were obtained by a sol-gel process using 3-azidopropyltriethoxysilane (azptes) as the silane agent. fe3o4@sio2-n-3 was directly reacted with n-propargyl iminodiacetic via click chemistry, in the presence of a cu(i) catalyst, to acquire the ida-modified fe3o4 nps. finally, through the addition of cu2+, the fe3o4@sio2 ida-cu np product was obtained. the morphology, structure and composition of the nps were characterized by transmission electron microscopy (tem), x-ray powder diffraction (xrd), fourier transform infrared (ftir) spectroscopy and x-ray photoelectron spectroscopy (xps). the resulting nps showed a strong magnetic response to an externally applied magnetic field, a high adsorption capacity and excellent specificity towards hemoglobin (hb). in addition, the fe3o4@sio2-ida-cu nps can be used for the selective removal of abundant hb protein in bovine and human blood samples. |
| WOS标题词 | science & technology ; physical sciences ; technology |
| 类目[WOS] | chemistry, multidisciplinary ; nanoscience & nanotechnology ; materials science, multidisciplinary ; physics, applied |
| 研究领域[WOS] | chemistry ; science & technology - other topics ; materials science ; physics |
| 关键词[WOS] | histidine-tagged proteins ; modified magnetic nanoparticles ; affinity-chromatography ; core/shell nanoparticles ; separation ; microspheres ; surfaces ; triazole ; azide ; shell |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000310976800026 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/143052]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China 2.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jian, Guiqin,Liu, Yuxing,He, Xiwen,et al. Click chemistry: a new facile and efficient strategy for the preparation of Fe3O4 nanoparticles covalently functionalized with IDA-Cu and their application in the depletion of abundant protein in blood samples[J]. nanoscale,2012,4(20):6336-6342. |
| APA | Jian, Guiqin,Liu, Yuxing,He, Xiwen,Chen, Langxing,&Zhang, Yukui.(2012).Click chemistry: a new facile and efficient strategy for the preparation of Fe3O4 nanoparticles covalently functionalized with IDA-Cu and their application in the depletion of abundant protein in blood samples.nanoscale,4(20),6336-6342. |
| MLA | Jian, Guiqin,et al."Click chemistry: a new facile and efficient strategy for the preparation of Fe3O4 nanoparticles covalently functionalized with IDA-Cu and their application in the depletion of abundant protein in blood samples".nanoscale 4.20(2012):6336-6342. |
入库方式： OAI收割
来源：大连化学物理研究所
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