Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography
文献类型：期刊论文
| 作者 | Yu, Hui1; Yin, Chenghua1; Jia, Cunyu1; Jin, Yu1; Ke, Yanxiong1; Liang, Xinmiao2 |
| 刊名 | chirality
 |
| 出版日期 | 2012-05-01 |
| 卷号 | 24期号:5页码:391-399 |
| 关键词 | chiral stationary phases click chemistry binaphthyl p-p interaction thermodynamic parameters |
| 英文摘要 | two click binaphthyl chiral stationary phases were synthesized and evaluated by liquid chromatography. their structures incorporate s-(-)-1,1'-binaphthyl moiety as the chiral selector and 1,2,3-triazole ring as the spacer. these chiral stationary phases (csps) allowed the efficient resolution for a wide range of racemic binol derivatives, particularly for nonpolar diether derivatives and 3-phenyl indolin-2-one analogs. the chromatographic data showed that the pp interaction was crucial for enantiorecognition of these csps. loss of enantioselectivity observed on csp3, which are lacking the triazole ring linkage, indicated that the triazole ring linkage took part in the enantioseparation process, although it was remote from the chiral selector of the csp. the substitution of the phenyl group at 6 and 6' positions can significantly improve the separation ability of the csp. the chiral recognition mechanism was also investigated by tracking the elution orders and studying the thermodynamic parameters. chirality 24:391399, 2012. copyright (c) 2012 wiley periodicals, inc. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | chemistry, medicinal ; chemistry, analytical ; chemistry, organic ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy ; chemistry |
| 关键词[WOS] | silica-gel ; efficient resolution ; acid-derivatives ; enantioseparation ; separation ; enantiomers ; recognition ; temperature ; mechanism ; binol |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000303237200006 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/143073]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Hui,Yin, Chenghua,Jia, Cunyu,et al. Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography[J]. chirality,2012,24(5):391-399. |
| APA | Yu, Hui,Yin, Chenghua,Jia, Cunyu,Jin, Yu,Ke, Yanxiong,&Liang, Xinmiao.(2012).Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography.chirality,24(5),391-399. |
| MLA | Yu, Hui,et al."Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography".chirality 24.5(2012):391-399. |
入库方式： OAI收割
来源：大连化学物理研究所
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