Investigation of Peptoid Chiral Stationary Phases Terminated with N '-Substituted Phenyl-L-proline/leucine Amide
文献类型：期刊论文
| 作者 | Wu Haibo1; Song Guangjun1; Liang Xinmiao1,2; Ke Yanxiong1 |
| 刊名 | chinese journal of chemistry
 |
| 出版日期 | 2012-12-01 |
| 卷号 | 30期号:12页码:2791-2797 |
| 关键词 | chiral stationary phase peptoid enantiomeric separation proline amide leucine amide |
| 英文摘要 | eight peptoid chiral stationary phases (csps) terminated with n'-substituted phenyl-l-proline or l-leucine amide were prepared and evaluated under normal phase mode. with 59 racemic analytes, we compared the enantiomeric separations on csps terminated with p-methylphenyl, p-chlorophenyl and unsubstituted phenyl. for short peptoid selectors containing only one s-n-(1-phenylethyl) glycine (nspe) unit, the terminal p-methyl substituent did not affect chiral recognition abilities significantly. in l-proline amide terminated csps, p-chloro substituent resulted in obviously inferior selectivity while in l-leucine amide terminated csps, it worked much better. longer peptoid selectors containing two more nspe units generally performed much better than the shorter ones, due to the great contributions of peptoid chain to chiral recognition. meanwhile, the effects of the terminal substituent on selectivity were found changed on these csps. for csps terminated with l-leucine amide, the terminal p-chloro substituent in longer selector no longer produced the best recognition ability; the csp with unsubstituted phenyl instead performed best. comparison of these peptoid csps varied in terminal substituents and chain length was conducted to gain a better understanding of the chiral recognition mechanism of this type csp and promote the development of more useful csps. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | performance liquid-chromatography ; capillary-electrophoresis ; drug enantiomers ; side-chains ; separation ; cellulose ; enantioseparation ; derivatives ; resolution ; selectors |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000312942500012 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/143137]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu Haibo,Song Guangjun,Liang Xinmiao,et al. Investigation of Peptoid Chiral Stationary Phases Terminated with N '-Substituted Phenyl-L-proline/leucine Amide[J]. chinese journal of chemistry,2012,30(12):2791-2797. |
| APA | Wu Haibo,Song Guangjun,Liang Xinmiao,&Ke Yanxiong.(2012).Investigation of Peptoid Chiral Stationary Phases Terminated with N '-Substituted Phenyl-L-proline/leucine Amide.chinese journal of chemistry,30(12),2791-2797. |
| MLA | Wu Haibo,et al."Investigation of Peptoid Chiral Stationary Phases Terminated with N '-Substituted Phenyl-L-proline/leucine Amide".chinese journal of chemistry 30.12(2012):2791-2797. |
入库方式： OAI收割
来源：大连化学物理研究所
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