Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/mass spectrometry
文献类型：期刊论文
| 作者 | Chen, Shili1; Wei, Cong2; Gao, Peng1; Kong, Hongwei1; Jia, Zhenhua2; Hu, Chunxiu1; Dai, Weidong1; Wu, Yiling2; Xu, Guowang1 |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2014-02-15 |
| 卷号 | 89页码:122-129 |
| 关键词 | Depression Allium macrostemon Lipidomics Acylcarnitine Liquid chromatography-mass spectrometry |
| 英文摘要 | the present study aimed to investigate the anti-depressive effect of the traditional chinese medicine allium macrostemon in a rat model of depression induced by exposure to chronic immobilization stress. lipid and acylcamitine metabolism were set into the focus of this study due to their key role in the pathogenesis of depression. plasma lipid profiling was performed by ultra fast liquid chromatography/ion trap-time of flight mass spectrometry. ultra-high performance liquid chromatography/triple quadrupole mass spectrometry was used to characterize the plasma acylcarnitine profile. principal component analysis (pca) revealed distinct differences in plasma lipid and acylcarnitine profiles of depressed rats from those in the control rats, which were also validated by univariate analysis. several lysophosphatidylcholines (lpc lpc (20:1), lpc (o-16:2), and lpc (o-18:3)) as well as most medium- and long-chain acylcarnitines were elevated, while some phosphatidylcholines (pc (32:1), pc (36:4 ->:5), pc (37:4), pc (38:4 ->:6), pc (40:6), pc (o-36:4), and pc (o-38:5)) and triglycerides (tg (58:12), tg (60:12), and tg (62:13 ->:14)) were decreased in the plasma of depressed rats. these changes indicate that depressed rats were associated with inflammatory conditions and an incomplete beta-oxidation of fatty acids. most of these dysregulated metabolites were returned to their normal levels after treatment with a. macrostemon according to pca and univariate analysis, highlighting the anti-depressive effect of this traditional chinese medicine. these results show that liquid chromatography/mass spectrometrybased quantitative metabolic profiling method is a useful tool to investigate the metabolic changes in depression and the anti-depressive effect of traditional chinese medicine. (c) 2013 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | to-moderate depression ; acid beta-oxidation ; mass-spectrometry ; endothelial-cells ; restraint stress ; cultured human ; lysophosphatidylcholine ; metabolome ; expression ; carnitine |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330487000019 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/143168]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Integrat Tradit & Western Med Res Acad Hebei Prov, Shijiazhuang 050035, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Shili,Wei, Cong,Gao, Peng,et al. Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/mass spectrometry[J]. journal of pharmaceutical and biomedical analysis,2014,89:122-129. |
| APA | Chen, Shili.,Wei, Cong.,Gao, Peng.,Kong, Hongwei.,Jia, Zhenhua.,...&Xu, Guowang.(2014).Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/mass spectrometry.journal of pharmaceutical and biomedical analysis,89,122-129. |
| MLA | Chen, Shili,et al."Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/mass spectrometry".journal of pharmaceutical and biomedical analysis 89(2014):122-129. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。