Functionalized mesoporous carbon nanoparticles for targeted chemo-photothermal therapy of cancer cells under near-infrared irradiation
文献类型：期刊论文
| 作者 | Xu, Guiju1,2; Liu, Shengju1,2; Niu, Huan1,2; Lv, Wenping1; Wu, Ren'an1 |
| 刊名 | rsc advances
 |
| 出版日期 | 2014 |
| 卷号 | 4期号:64页码:33986-33997 |
| 英文摘要 | chemo-photothermal therapy with the combination of chemotherapy and photothermal therapy has emerged as a promising anticancer treatment for its synergistic effects. in this work, the functionalized mesoporous carbon nanoparticles (fa/pei/o-mcn) were constructed by modifying the mesoporous carbon nanoparticles (mcn) with polyethylenimine (pei) and folic acid (fa) for the targeted chemophotothermal therapy. the fa/pei/o-mcn exhibited strong light absorption and high photothermal conversion efficiency in the near-infrared (nir) region due to the graphitic structure of mcn. meanwhile, fa/pei/o-mcn displayed high drug loading capacity using doxorubicin hydrochloride (dox) as a model drug. flow cytometry analysis and competitive binding experiments verified that the fa modification could significantly enhance the uptake of fa/pei/o-mcn by hela cells with folate receptors (fr) over-expressing. comparing with chemotherapy or photothermal therapy alone, the dox-loaded fa/pei/omcn demonstrated the synergistic effects and resulted in the higher therapeutic efficacy. we believe that the fa/pei/o-mcn could be applied as an efficient chemo-photothermal platform to realize the targeted synergistic therapy. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | coated gold nanorods ; reduced graphene oxide ; drug-delivery system ; silica nanoparticles ; optical-properties ; controlled-release ; nanotubes ; light ; nanospheres ; doxorubicin |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000341287300042 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/143169]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Guiju,Liu, Shengju,Niu, Huan,et al. Functionalized mesoporous carbon nanoparticles for targeted chemo-photothermal therapy of cancer cells under near-infrared irradiation[J]. rsc advances,2014,4(64):33986-33997. |
| APA | Xu, Guiju,Liu, Shengju,Niu, Huan,Lv, Wenping,&Wu, Ren'an.(2014).Functionalized mesoporous carbon nanoparticles for targeted chemo-photothermal therapy of cancer cells under near-infrared irradiation.rsc advances,4(64),33986-33997. |
| MLA | Xu, Guiju,et al."Functionalized mesoporous carbon nanoparticles for targeted chemo-photothermal therapy of cancer cells under near-infrared irradiation".rsc advances 4.64(2014):33986-33997. |
入库方式： OAI收割
来源：大连化学物理研究所
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