Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta
文献类型：期刊论文
| 作者 | Zhang, Hong1; Zhang, Dan-Dan3; Lao, Yuan-Zhi1; Fu, Wen-Wei1; Liang, Shuang1; Yuan, Qing-Hong4; Yang, Ling5; Xu, Hong-Xi1,2 |
| 刊名 | journal of natural products
 |
| 出版日期 | 2014-07-01 |
| 卷号 | 77期号:7页码:1700-1707 |
| 英文摘要 | five new prenylated benzoylphloroglucinol derivatives, garciesculentones a-e (1-5), a new xanthone, garciesculenxanthone a (6), and 15 known compounds were isolated from the petroleum ether extract and the etoac-soluble fraction of a 80% (v/v) etoh extract of garcinia esculenta. the structures of the new compounds were elucidated by 1d- and 2d-nmr spectroscopic analysis and mass spectrometry. experimental and calculated ecd and a convenient modified mosher's method were used to determine the absolute configurations. the cytotoxicity of these compounds were evaluated by mtt assay against three human cancer cell lines (hepg2, mcf-7, and mda-mb-231) and against normal hepatic cells (hl-7702). in addition, these isolates were evaluated for their inhibitory effects on interferon-gamma plus lipopolysaccharide-induced nitric oxide production in raw264.7 cells. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | plant sciences ; chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | plant sciences ; pharmacology & pharmacy |
| 关键词[WOS] | bioassay-guided isolation ; colon-cancer cells ; gamma-mangostin ; polyprenylated xanthones ; benzophenone derivatives ; absolute-configuration ; natural-products ; oblongifolia ; leaves ; fruits |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000339604300021 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/143171]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Murad Res Ctr Modernized Chinese Med, Shanghai 201203, Peoples R China 4.E China Normal Univ, Dept Phys, Shanghai 200241, Peoples R China 5.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hong,Zhang, Dan-Dan,Lao, Yuan-Zhi,et al. Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta[J]. journal of natural products,2014,77(7):1700-1707. |
| APA | Zhang, Hong.,Zhang, Dan-Dan.,Lao, Yuan-Zhi.,Fu, Wen-Wei.,Liang, Shuang.,...&Xu, Hong-Xi.(2014).Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta.journal of natural products,77(7),1700-1707. |
| MLA | Zhang, Hong,et al."Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta".journal of natural products 77.7(2014):1700-1707. |
入库方式： OAI收割
来源：大连化学物理研究所
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