Enantioselective Copper-Catalyzed Decarboxylative Propargylic Alkylation of Propargyl beta-Ketoesters with a Chiral Ketimine P,N,N-Ligand
文献类型：期刊论文
| 作者 | Zhu, Fu-Lin1,2; Zou, Yuan1; Zhang, De-Yang1,2; Wang, Ya-Hui1; Hu, Xin-Hu1; Chen, Song1; Xu, Jie1; Hu, Xiang-Ping1 |
| 刊名 | angewandte chemie-international edition
 |
| 出版日期 | 2014-01-27 |
| 卷号 | 53期号:5页码:1410-1414 |
| 关键词 | alkylation asymmetric catalysis copper ligand design synthetic methods |
| 英文摘要 | the first enantioselective copper-catalyzed decarboxylative propargylic alkylation has been developed. treatment of propargyl beta-ketoesters with a catalyst, prepared in situ from [cu(ch3cn)(4)bf4] and a newly developed chiral tridentate ketimine p,n,n-ligand under mild reaction conditions, generates beta-ethynyl ketones in good yields and with high enantioselectivities without requiring the pregeneration of ketone enolates. this new process provides facile access to a range of chiral beta-ethynyl ketones in a highly enantioenriched form. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | substitution-reactions ; conjugate addition ; terminal alkynes ; keto-esters ; amination ; amines ; hydrogenolysis ; complexes ; acetates ; scope |
| 收录类别 | SCI ; IC ; CCR |
| 语种 | 英语 |
| WOS记录号 | WOS:000336504500041 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/143181]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Fu-Lin,Zou, Yuan,Zhang, De-Yang,et al. Enantioselective Copper-Catalyzed Decarboxylative Propargylic Alkylation of Propargyl beta-Ketoesters with a Chiral Ketimine P,N,N-Ligand[J]. angewandte chemie-international edition,2014,53(5):1410-1414. |
| APA | Zhu, Fu-Lin.,Zou, Yuan.,Zhang, De-Yang.,Wang, Ya-Hui.,Hu, Xin-Hu.,...&Hu, Xiang-Ping.(2014).Enantioselective Copper-Catalyzed Decarboxylative Propargylic Alkylation of Propargyl beta-Ketoesters with a Chiral Ketimine P,N,N-Ligand.angewandte chemie-international edition,53(5),1410-1414. |
| MLA | Zhu, Fu-Lin,et al."Enantioselective Copper-Catalyzed Decarboxylative Propargylic Alkylation of Propargyl beta-Ketoesters with a Chiral Ketimine P,N,N-Ligand".angewandte chemie-international edition 53.5(2014):1410-1414. |
入库方式： OAI收割
来源：大连化学物理研究所
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