Identification of Two Novel Modifications at Tryptophan Residues
文献类型：期刊论文
| 作者 | Zheng, Shuzhen1; Zhang, Kai1,2,3; Tian, Shanshan2,3; He, Xiwen1; Zhang, Yukui1,4 |
| 刊名 | journal of the american society for mass spectrometry
 |
| 出版日期 | 2015-10-01 |
| 卷号 | 26期号:10页码:1787-1790 |
| 关键词 | Proteomics Mass spectrometry Post-translational modifications Tryptophan modifications |
| 通讯作者 | 张锴 |
| 英文摘要 | protein post-translational modifications (ptms) play important roles in cellular physiology. mass spectrometry (ms) has been developed into a powerful tool to identify all possible protein modifications. herein, we describe our efforts to deduce the structures of two unknown modifications at tryptophan (trp) residues (w + 92 da and w + 108 da). the two modifications were further confirmed by aligning the ms/ms fragmentation of synthetic peptide with in-vivo peptide identified. finally, the mimic experiment elucidated how two trp modifications occur. this study, therefore, expands current knowledge of trp modifications. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences ; technology |
| 学科主题 | 物理化学 |
| 类目[WOS] | biochemical research methods ; chemistry, analytical ; chemistry, physical ; spectroscopy |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry ; spectroscopy |
| 关键词[WOS] | posttranslational modifications ; mass-spectrometry ; proteins ; oxidation ; products ; damage ; ptmap ; ms |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361073200017 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/143694]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China 2.Tianjin Med Univ, Dept Biochem & Mol Biol, Tianjin 300070, Peoples R China 3.Tianjin Med Univ, Tianjin Key Lab Med Epigenet, Tianjin 300070, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Shuzhen,Zhang, Kai,Tian, Shanshan,et al. Identification of Two Novel Modifications at Tryptophan Residues[J]. journal of the american society for mass spectrometry,2015,26(10):1787-1790. |
| APA | Zheng, Shuzhen,Zhang, Kai,Tian, Shanshan,He, Xiwen,&Zhang, Yukui.(2015).Identification of Two Novel Modifications at Tryptophan Residues.journal of the american society for mass spectrometry,26(10),1787-1790. |
| MLA | Zheng, Shuzhen,et al."Identification of Two Novel Modifications at Tryptophan Residues".journal of the american society for mass spectrometry 26.10(2015):1787-1790. |
入库方式： OAI收割
来源：大连化学物理研究所
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