Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells
文献类型：期刊论文
| 作者 | Zhao, Tong1,2; He, Xi-Wen1,2; Li, Wen-You1,2; Zhang, Yu-Kui1,2,3 |
| 刊名 | journal of materials chemistry b
 |
| 出版日期 | 2015 |
| 卷号 | 3期号:11页码:2388-2394 |
| 通讯作者 | 李文友 |
| 英文摘要 | transferrin (trf)-functionalized copper nanoclusters (trf-cu ncs) were fabricated as a novel red-emitting fluorescent probe for the targeted bioimaging of cancer cells. a one-pot approach was developed to prepare stable, water-soluble and red-emitting trf-cu ncs at room temperature via a biomineralization process with trf as the template and ascorbic acid as a green reducing agent. trf acted not only as a stabilizer and reducer, but also as a functional ligand for targeting the transferrin receptor. the asprepared trf-cu ncs showed an intense red fluorescence with a red emission peak at 670 nm (quantum yield about 6.2%), suggesting that the probe could potentially be used for bioimaging in vivo. the developed trf-cu ncs had excellent photostability and water solubility and exhibited a high specificity to transferrin receptor with negligible cytotoxicity. the probe was successfully applied to the targeted bioimaging of hela cells. |
| 学科主题 | 物理化学 |
| WOS标题词 | science & technology ; technology |
| 类目[WOS] | materials science, biomaterials |
| 研究领域[WOS] | materials science |
| 关键词[WOS] | fluorescent gold nanoclusters ; one-pot synthesis ; quantum clusters ; emission ; peptide ; water ; nanoparticles ; fabrication ; templates ; sensor |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350983400015 |
| 公开日期 | 2015-11-17 |
| 源URL | [http://159.226.238.44/handle/321008/143699]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Nankai Univ, State Key Lab Med Chem Biol, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China 2.Nankai Univ, Res Ctr Analyt Sci, Coll Chem, Tianjin 300071, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Tong,He, Xi-Wen,Li, Wen-You,et al. Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells[J]. journal of materials chemistry b,2015,3(11):2388-2394. |
| APA | Zhao, Tong,He, Xi-Wen,Li, Wen-You,&Zhang, Yu-Kui.(2015).Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells.journal of materials chemistry b,3(11),2388-2394. |
| MLA | Zhao, Tong,et al."Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells".journal of materials chemistry b 3.11(2015):2388-2394. |
入库方式： OAI收割
来源：大连化学物理研究所
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