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Metabonomics in Ulcerative Colitis: Diagnostics, Biomarker Identification, And Insight into the Pathophysiology
文献类型：期刊论文
| 作者 | Bjerrum, Jacob T.1; Nielsen, Ole H.1; Hao, Fuhua2 ; Tang, Huiru2; Nicholson, Jeremy K.3; Wang, Yulan2; Olsen, Jorgen4
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| 刊名 | JOURNAL OF PROTEOME RESEARCH
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| 出版日期 | 2010-02-01 |
| 卷号 | 9期号:2页码:954-962 |
| 关键词 | biomarker identification diagnostics metabonomics NMR spectroscopy ulcerative colitis |
| 英文摘要 | Nuclear magnetic resonance (NMR) spectroscopy and appropriate multivariate statistical analyses have been employed on mucosal colonic biopsies, colonocytes, lymphocytes, and urine from patients with ulcerative colitis (UC) and controls in order to explore the diagnostic possibilities, define new potential biomarkers, and generate a better understanding of the pathophysiology. Samples were collected from patients with active UC (n = 41), quiescent UC (n = 33), and from controls (n = 25) and analyzed by NMR spectroscopy. Data analysis was carried out by principal component analysis and orthogonal-projection to latent structure-discriminant analysis using the SIMCA P+11 software package (Umetrics, Umea, Sweden) and Matlab environment. Significant differences between controls and active UC were discovered in the metabolic profiles of biopsies and colonocytes. In the biopsies from patients with active UC higher levels of antioxidants and of a range of amino acids, but lower levels of lipid, glycerophosphocholine (GPC), myo-inositol, and betaine were found, whereas the colonocytes only displayed low levels of GPC, myo-inositol and choline. Interestingly, 20% of inactive UC patients had similar profiles to those who were in an active state. This study demonstrates the possibilities of metabonomics as a diagnostic tool in active and quiescent UC and provides new insight into pathophysiologic mechanisms. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | INFLAMMATORY-BOWEL-DISEASE ; MAGNETIC-RESONANCE SPECTROSCOPY ; SPINNING H-1-NMR SPECTROSCOPY ; ACID-INDUCED COLITIS ; FACTOR-KAPPA-B ; CROHNS-DISEASE ; GENE-EXPRESSION ; COLONIC-MUCOSA ; METABOLISM ; GLUTAMINE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000274269400031 |
| 公开日期 | 2015-12-01 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8199]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Univ Copenhagen, Herlev Hosp, Med Sect, Dept Gastroenterol, DK-2730 Herlev, Denmark 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Beijing 100864, Peoples R China 3.Univ London Imperial Coll Sci Technol & Med, Dept Biomol Med, London SW7 2AZ, England 4.Univ Copenhagen, Panum Inst, Dept Cellular & Mol Med, DK-2730 Herlev, Denmark |
| 推荐引用方式 GB/T 7714 | Bjerrum, Jacob T.,Nielsen, Ole H.,Hao, Fuhua,et al. Metabonomics in Ulcerative Colitis: Diagnostics, Biomarker Identification, And Insight into the Pathophysiology[J]. JOURNAL OF PROTEOME RESEARCH,2010,9(2):954-962. |
| APA | Bjerrum, Jacob T..,Nielsen, Ole H..,Hao, Fuhua.,Tang, Huiru.,Nicholson, Jeremy K..,...&Olsen, Jorgen.(2010).Metabonomics in Ulcerative Colitis: Diagnostics, Biomarker Identification, And Insight into the Pathophysiology.JOURNAL OF PROTEOME RESEARCH,9(2),954-962. |
| MLA | Bjerrum, Jacob T.,et al."Metabonomics in Ulcerative Colitis: Diagnostics, Biomarker Identification, And Insight into the Pathophysiology".JOURNAL OF PROTEOME RESEARCH 9.2(2010):954-962. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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