Metabonomic Studies of Biochemical Changes in the Serum of Rats by Intratracheally Instilled TiO2 Nanoparticles
文献类型：期刊论文
| 作者 | Tang, Meng1,2; Zhang, Ting1,2; Xue, Yuying1,2; Wang, Shu1,2; Huang, Mingming3; Yang, Yang1,2; Lu, Minyu1,2; Lei, Hao3; Kong, Lu1,2; Wang, Yiqing1,2 |
| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
 |
| 出版日期 | 2011-04-01 |
| 卷号 | 11期号:4页码:3065-3074 |
| 关键词 | TiO2 Nanoparticle Metabonomics Nanotoxicity Serum |
| 英文摘要 | In vivo behavior of nanoparticles and interactions between nanoparticles and organisms are key components of nanotoxicology. In this study, the biochemical compositions of rat serum exposed to TiO2 nanoparticles (nano-TiO2) by intratracheal instillation at low (0.8 mg/kg), medium (4 mg/kg) and high doses (20 mg/kg) were investigated using H-1-NMR techniques with pattern recognition methods. Serum biochemical assays, as well as histopathological and transmission electron microscopy (TEM) examinations of tissues were performed. H-1-NMR spectra and pattern recognition analyses of nano-TiO2 treated animals showed increased serum levels of ketone bodies, choline, low density lipoprotein (LDL), alanine and GLU, and decreased levels of lactate, creatine and pyruvate. Clinical chemistry analyses of serum showed increased levels of lactate dehydrogenase, aspartate aminotransferase, and alkaline phosphatase, as well as increased levels of blood urea nitrogen and creatinine, indicating slight liver and kidney injury. Furthermore, TEM provided an analysis of particle-related structural changes of the lungs, liver and kidneys, and revealed that the localization of nanoparticles within cells induced apoptosis. The damage to the target organs was associated with the perturbation of energy metabolism. Serum H-1-NMR spectra, in combination with pattern recognition techniques, proved to be an efficient and simple metabonomic method to depict the metabolic changes produced by intratracheally-instilled nano-TiO2. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 关键词[WOS] | TITANIUM-DIOXIDE NANOPARTICLES ; PULMONARY TOXICITY ; H-1-NMR SPECTROSCOPY ; PARTICLES ; INHALATION ; MICE ; NANOMATERIALS ; RESPONSES ; SAFETY ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000289176100043 |
| 公开日期 | 2015-12-01 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8208]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Southeast Univ, Sch Publ Hlth, Minist Educ, Key Lab Environm Med & Engn, Nanjing 210009, Peoples R China 2.Southeast Univ, Key Lab Biomat & Device Jiangsu Prov, Nanjing 210009, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei Province, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Meng,Zhang, Ting,Xue, Yuying,et al. Metabonomic Studies of Biochemical Changes in the Serum of Rats by Intratracheally Instilled TiO2 Nanoparticles[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2011,11(4):3065-3074. |
| APA | Tang, Meng.,Zhang, Ting.,Xue, Yuying.,Wang, Shu.,Huang, Mingming.,...&Pu, Yuepu.(2011).Metabonomic Studies of Biochemical Changes in the Serum of Rats by Intratracheally Instilled TiO2 Nanoparticles.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,11(4),3065-3074. |
| MLA | Tang, Meng,et al."Metabonomic Studies of Biochemical Changes in the Serum of Rats by Intratracheally Instilled TiO2 Nanoparticles".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 11.4(2011):3065-3074. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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