Retinal Metabolic Changes in an Experimental Model of Optic Nerve Transection by Ex Vivo H-1 Magnetic Resonance Spectroscopy
文献类型：期刊论文
| 作者 | Li, Shuang1; Huang, Mingming2; Wang, Xinghua1,2; Wang, Xuxia; Chen, Fei1; Lei, Hao2; Jiang, Fagang1 |
| 刊名 | NEUROCHEMICAL RESEARCH
 |
| 出版日期 | 2011-12-01 |
| 卷号 | 36期号:12页码:2427-2433 |
| 关键词 | Optic nerve transection Glutamate GABA Magnetic resonance spectroscopy Metabolism |
| 英文摘要 | This study aims to investigate the retinal metabolic processes in a rat axotomy model. Retinal metabolic changes in optic nerve transection (ONT) rat model were analyzed by H-1 magnetic resonance spectroscopy (H-1-MRS). Retinal ganglion cells (RGCs) densities were assessed from retinal whole mounts. The retina was stained immunohistochemically with glial fibrillary acidic protein (GFAP). The results showed that the retina in ONT rats had significantly decreased concentrations of gamma-aminobutyric acid (GABA), N-acetylaspartate (NAA), taurine (Tau), creatine (Cr) and increased concentrations of alanine (Ala) compared with control. Examination of glutamate (Glu), glutamine (Gln) and Glx (Glu + Gln) concentrations disclosed no significant differences. The mean density of RGCs reduced from 2,249 +/- A 87 cells/mm(2) in control group to 320 +/- A 56 cells/mm(2) in ONT group. GFAP immunoreactivity was markedly higher in ONT group than that in control group. The retinal metabolism after ONT was associated with neurotransmitter recycling/production perturbation, as well as other metabolic disequilibrium. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Neurosciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 关键词[WOS] | TRAUMATIC BRAIN-INJURY ; RESOLUTION H-1-NMR SPECTROSCOPY ; PROTON MR SPECTROSCOPY ; GANGLION-CELLS ; RAT RETINA ; IN-VIVO ; GLUTAMATE RECEPTORS ; N-ACETYLASPARTATE ; VERTEBRATE RETINA ; NEURONAL DEATH |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000296516500028 |
| 公开日期 | 2015-12-01 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8212]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Ophthalmol, Wuhan 430022, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Shuang,Huang, Mingming,Wang, Xinghua,et al. Retinal Metabolic Changes in an Experimental Model of Optic Nerve Transection by Ex Vivo H-1 Magnetic Resonance Spectroscopy[J]. NEUROCHEMICAL RESEARCH,2011,36(12):2427-2433. |
| APA | Li, Shuang.,Huang, Mingming.,Wang, Xinghua.,Wang, Xuxia.,Chen, Fei.,...&Jiang, Fagang.(2011).Retinal Metabolic Changes in an Experimental Model of Optic Nerve Transection by Ex Vivo H-1 Magnetic Resonance Spectroscopy.NEUROCHEMICAL RESEARCH,36(12),2427-2433. |
| MLA | Li, Shuang,et al."Retinal Metabolic Changes in an Experimental Model of Optic Nerve Transection by Ex Vivo H-1 Magnetic Resonance Spectroscopy".NEUROCHEMICAL RESEARCH 36.12(2011):2427-2433. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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