Plasma Metabonomic Analysis with H-1 Nuclear Magnetic Resonance Revealing the Relationship of Different Tumors and the Disease Homology Theory of Traditional Uyghur Medicine
文献类型：期刊论文
| 作者 | Mamtimin, Batur1,2; Upur, Halmurat1; Hao Fu-hua3; Matsidik, Aynur4; Rahim, Rena4 |
| 刊名 | CHINESE JOURNAL OF INTEGRATIVE MEDICINE
 |
| 出版日期 | 2011-02-01 |
| 卷号 | 17期号:2页码:111-115 |
| 关键词 | tumor abnormal Savda traditional Uyghur medicine metabonomics |
| 英文摘要 | Objective: To investigate the plasma samples obtained from tumor patients using H-1 nuclear magnetic resonance (NMR) spectroscopy, and find the biochemical foundation of abnormal Savda described in traditional Uyghur medicine. Methods: A total of 170 tumor patients with abnormal Savda syndrome who were confirmed clinically were enrolled in this study, and 50 healthy volunteers were set up as controls. The plasma H-1 NMR spectra were analyzed using the orthogonal projection to latent structure with discriminant analysis (OPLS-DA) method with unit variance scaling. The discriminative significance of the metabolites was determined using the Pearson's product-moment correlation coefficient. Results: Compared with the healthy controls, the tumor patients with abnormal Savda syndrome had uniformly correlative low levels of leucine, isoleucine, valine, histidine, tyrosine, alanine, glutamine, creatine, inositol, alpha -glucose, and beta -glucose (P<0.05), but had significantly high levels of formate, malonic acid, acetone, acetate, acetoacetate, pyruvate, beta -hydroxy butyrate, carnitine and lipidtemns such as very low density lipoprotein, low density lipoprotein and unsaturated lipids (P<0.05). Conclusion: Tumor patients with abnormal Savda syndrome had similar metabolic changes and characteristics, which indicated a similar pathogenetic process and provides some biochemical basis for traditional Uyghur medicine theory. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Integrative & Complementary Medicine |
| 研究领域[WOS] | Integrative & Complementary Medicine |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000286908700007 |
| 公开日期 | 2015-12-01 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8238]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Xinjiang Med Univ, Coll Pharm, Urumqi 830011, Peoples R China 2.Zhongnan Univ, Coll Pharm, Changsha 410007, Hunan, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Mol & Atom Phys, Wuhan 430071, Peoples R China 4.Xinjiang Med Univ, Fac Tradit Uyghur Med, Urumqi 830011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mamtimin, Batur,Upur, Halmurat,Hao Fu-hua,et al. Plasma Metabonomic Analysis with H-1 Nuclear Magnetic Resonance Revealing the Relationship of Different Tumors and the Disease Homology Theory of Traditional Uyghur Medicine[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2011,17(2):111-115. |
| APA | Mamtimin, Batur,Upur, Halmurat,Hao Fu-hua,Matsidik, Aynur,&Rahim, Rena.(2011).Plasma Metabonomic Analysis with H-1 Nuclear Magnetic Resonance Revealing the Relationship of Different Tumors and the Disease Homology Theory of Traditional Uyghur Medicine.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,17(2),111-115. |
| MLA | Mamtimin, Batur,et al."Plasma Metabonomic Analysis with H-1 Nuclear Magnetic Resonance Revealing the Relationship of Different Tumors and the Disease Homology Theory of Traditional Uyghur Medicine".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 17.2(2011):111-115. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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