Conformational flexibility of deoxyoligonucleotide d(GGTATACC)(2) in water
文献类型：期刊论文
| 作者 | Yan, JL; Zhang, YJ; Mao, XA; Shen, LF |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 1998-05-01 |
| 卷号 | 30期号:3页码:277-282 |
| 关键词 | d(GGTATACC)(2) three-dimensional conformation in water flexibility of T-5 residue |
| 英文摘要 | AT-rich deoxyoligonucleotide provides a binding site possibly at the minor groove for some antitumor drugs by hydrophobic or Van der Waals interactions. In this paper, it is demonstrated by study of d(GGTATACC)(2) that the DNA-drug interaction may be dependent on the structural flexibility at the minor groove. The solution structure of d(GGTATACC)(2) in water is described by distance-restrained molecular dynamics calculation and it is suggested that d(GGTATACC)(2) in solution maintains the double helix of B-type with trans conformations of base to sugar and C2'-endo conformation for the deoxyribose ring. It is found that the end moieties GGT and ACC are relatively rigid while Tg residue is flexible, which may account for the activity of the minor groove. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | AQUEOUS-SOLUTION
; D(G-G-T-A-T-A-C-C) DUPLEX
; DNA DUPLEXES
; |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000073835600013 |
| 公开日期 | 2015-12-01 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8323]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Cent China Normal Univ, Ctr Anal & Testing, Wuhan 430079, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, JL,Zhang, YJ,Mao, XA,et al. Conformational flexibility of deoxyoligonucleotide d(GGTATACC)(2) in water[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,1998,30(3):277-282. |
| APA | Yan, JL,Zhang, YJ,Mao, XA,&Shen, LF.(1998).Conformational flexibility of deoxyoligonucleotide d(GGTATACC)(2) in water.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,30(3),277-282. |
| MLA | Yan, JL,et al."Conformational flexibility of deoxyoligonucleotide d(GGTATACC)(2) in water".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 30.3(1998):277-282. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。