Impurity profiling in bulk pharmaceutical batches using F-19 NMR spectroscopy and distinction between monomeric and dimeric impurities by NMR-based diffusion measurements
文献类型：期刊论文
| 作者 | Mistry, N; Ismail, IM; Farrant, RD; Liu, ML; Nicholson, JK; Lindon, JC |
| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 1999-03-01 |
| 卷号 | 19期号:3-4页码:511-517 |
| 关键词 | NMR F-19 diffusion impurity fluticasone production |
| 英文摘要 | The impurity profile of production batches of fluorine-containing drugs can be characterised efficiently using F-19 NMR spectroscopy. This yields the number and proportions of impurities in the bulk drug to a level of approximate to 0.1 mole% in a few minutes of NMR experiment time. The approach has been exemplified using a partially purified batch of the steroidal product fluticasone propionate, the impurities in which include a number of dimeric species. Further distinction between the monomer and dimer impurities has been achieved through high resolution chemical shift-resolved NMR measurement of molecular diffusion coefficients on the intact mixture using F-19 NMR spectroscopy. The ability of NMR-based diffusion coefficient determination to distinguish between monomeric and dimeric substances was validated using a standard mixture of authentic materials containing both monomers and dimers. (C) 1999 Elsevier Science B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine |
| 类目[WOS] | Chemistry, Analytical ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Chemistry ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000078549100027 |
| 公开日期 | 2015-12-01 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8368]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Univ London Imperial Coll Sci Technol & Med, Div Biomed Sci, London SW7 2AZ, England 2.GlaxoWellcome Med Res Ctr, Chem Anal Dept, Stevenage SG1 2NY, Herts, England 3.GlaxoWellcome, Int Dev, Ware SG12 0DP, Herts, England 4.GlaxoWellcome Med Res Ctr, Phys Sci Unit, Stevenage SG1 2NY, Herts, England 5.NW Univ Xian, Instrumental Anal Res Ctr, Xian 710069, Peoples R China 6.Chinese Acad Sci, Wuhan Inst Phys & Math, Lab Magnet Resonance, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mistry, N,Ismail, IM,Farrant, RD,et al. Impurity profiling in bulk pharmaceutical batches using F-19 NMR spectroscopy and distinction between monomeric and dimeric impurities by NMR-based diffusion measurements[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,1999,19(3-4):511-517. |
| APA | Mistry, N,Ismail, IM,Farrant, RD,Liu, ML,Nicholson, JK,&Lindon, JC.(1999).Impurity profiling in bulk pharmaceutical batches using F-19 NMR spectroscopy and distinction between monomeric and dimeric impurities by NMR-based diffusion measurements.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,19(3-4),511-517. |
| MLA | Mistry, N,et al."Impurity profiling in bulk pharmaceutical batches using F-19 NMR spectroscopy and distinction between monomeric and dimeric impurities by NMR-based diffusion measurements".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 19.3-4(1999):511-517. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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