NMR spectroscopic diffusion, chemical shift and linewidth measurements of low-affinity binding of ibuprofen enantiomers to human serum albumin
文献类型：期刊论文
| 作者 | Ma, YH; Liu, ML; Mao, XA; Nicholson, JK; Lindon, JC |
| 刊名 | MAGNETIC RESONANCE IN CHEMISTRY
 |
| 出版日期 | 1999-04-01 |
| 卷号 | 37期号:4页码:269-273 |
| 关键词 | NMR ibuprofen enantiomers human serum albumin binding diffusion coefficient |
| 英文摘要 | The binding of racemic, (R)(-) and (S)(+)-ibuprofen (IBP) to human serum albumin (HSA) was studied using NMR spectroscopy. Having saturated the tight binding sites, the extent of weak binding was then investigated. The molecular diffusion coefficients of IBP in HSA solution at different concentration ratios indicate that there is no significant difference in binding capacity of the two enantiomers of IBP to HSA at high IBP:HSA ratios. However, there are chemical shift and linewidth changes in the (NMR)-N-1 spectrum of IBP in the presence of HSA induced by the binding and this suggests that the major binding interaction involves the sec-butyl chain of the IBP molecule binding to HSA in hydrophobic pockets. Copyright (C) 1999 John Wiley & Sons, Ltd. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Spectroscopy |
| 研究领域[WOS] | Chemistry ; Spectroscopy |
| 关键词[WOS] | NUCLEAR-MAGNETIC-RESONANCE ; PROTEIN-BINDING ; DRUGS ; SITE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000079618000003 |
| 公开日期 | 2015-12-01 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8406]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Lab Magnet Resonance Atom & Mol Phys, Wuhan 430071, Peoples R China 2.NW Univ Xian, Instrumentat Anal Res Ctr, Xian 710069, Peoples R China 3.Univ London Imperial Coll Sci Technol & Med, Ctr Biol Chem, Div Biomed Sci, London SW7 2AA, England |
| 推荐引用方式 GB/T 7714 | Ma, YH,Liu, ML,Mao, XA,et al. NMR spectroscopic diffusion, chemical shift and linewidth measurements of low-affinity binding of ibuprofen enantiomers to human serum albumin[J]. MAGNETIC RESONANCE IN CHEMISTRY,1999,37(4):269-273. |
| APA | Ma, YH,Liu, ML,Mao, XA,Nicholson, JK,&Lindon, JC.(1999).NMR spectroscopic diffusion, chemical shift and linewidth measurements of low-affinity binding of ibuprofen enantiomers to human serum albumin.MAGNETIC RESONANCE IN CHEMISTRY,37(4),269-273. |
| MLA | Ma, YH,et al."NMR spectroscopic diffusion, chemical shift and linewidth measurements of low-affinity binding of ibuprofen enantiomers to human serum albumin".MAGNETIC RESONANCE IN CHEMISTRY 37.4(1999):269-273. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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